1,3,4-恶二唑环结合（嘧啶-5-基）吲哚嗪抗癌剂的合成及生物学评价

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2025-05-16 DOI:10.1016/j.cdc.2025.101190

V.Naveen Kumar , Muralasetti Nookaraju , Kumara Swamy Jella , Somaiah Nalla

{"title":"1,3,4-恶二唑环结合（嘧啶-5-基）吲哚嗪抗癌剂的合成及生物学评价","authors":"V.Naveen Kumar , Muralasetti Nookaraju , Kumara Swamy Jella , Somaiah Nalla","doi":"10.1016/j.cdc.2025.101190","DOIUrl":null,"url":null,"abstract":"<div><div>A new series of 1,3,4-oxadiazole rings incorporated (pyrimidin-5-yl)indolizine (10a-j) and their structures were characterized by analytical data. Further, all these newly synthesized compounds (10a-j) were examined for their preliminary <em>In vitro</em> anticancer profiles towards four human cancer cell lines, such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer (A2780) by employing the MTT method. The majority of the compounds exhibited moderate to excellent anticancer activity, as indicated by the results. Notably, compound 10i had the most promising activity.</div></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":"57 ","pages":"Article 101190"},"PeriodicalIF":2.2180,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and Biological Evaluation of 1,3,4-oxadiazole ring incorporated (pyrimidin-5-yl)indolizine as Anticancer Agents\",\"authors\":\"V.Naveen Kumar , Muralasetti Nookaraju , Kumara Swamy Jella , Somaiah Nalla\",\"doi\":\"10.1016/j.cdc.2025.101190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A new series of 1,3,4-oxadiazole rings incorporated (pyrimidin-5-yl)indolizine (10a-j) and their structures were characterized by analytical data. Further, all these newly synthesized compounds (10a-j) were examined for their preliminary <em>In vitro</em> anticancer profiles towards four human cancer cell lines, such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer (A2780) by employing the MTT method. The majority of the compounds exhibited moderate to excellent anticancer activity, as indicated by the results. Notably, compound 10i had the most promising activity.</div></div>\",\"PeriodicalId\":269,\"journal\":{\"name\":\"Chemical Data Collections\",\"volume\":\"57 \",\"pages\":\"Article 101190\"},\"PeriodicalIF\":2.2180,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Data Collections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405830025000126\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405830025000126","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}

引用次数: 0

摘要

用分析数据对含有（嘧啶-5-基）吲哚嗪（10a-j）的1,3,4-恶二唑环进行了结构表征。此外，采用MTT法对所有新合成的化合物（10a-j）对人乳腺癌（MCF-7）、人肺癌（A549）、人结肠癌（Colo-205）和人卵巢癌（A2780）等4种人癌细胞进行了初步的体外抑癌活性检测。结果表明，大多数化合物表现出中等至优异的抗癌活性。值得注意的是，化合物10i的活性最有希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis and Biological Evaluation of 1,3,4-oxadiazole ring incorporated (pyrimidin-5-yl)indolizine as Anticancer Agents

A new series of 1,3,4-oxadiazole rings incorporated (pyrimidin-5-yl)indolizine (10a-j) and their structures were characterized by analytical data. Further, all these newly synthesized compounds (10a-j) were examined for their preliminary In vitro anticancer profiles towards four human cancer cell lines, such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) and human ovarian cancer (A2780) by employing the MTT method. The majority of the compounds exhibited moderate to excellent anticancer activity, as indicated by the results. Notably, compound 10i had the most promising activity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

期刊介绍： Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.