用丙炔碳酸酯铜催化醛的二烯化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-20 DOI:10.1021/acs.orglett.5c0121810.1021/acs.orglett.5c01218

Xiang Lei, Peng Luo, Wennan Dong*, Caiyi Ren, Qinqin Cui, Jinggong Liu, Xiang-Wen Kong, Shuang Yang* and Xinqiang Fang*,

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引用次数: 0

摘要

在B2pin2的存在下，用丙炔碳酸酯成功地进行了铜催化醛的二烯化反应，从而合成了多种取代的1,3-丁二烯基-2-甲醇（BDCs）。这种创新的方法绕过了对烯类试剂的要求，并提供了一种允许进入bdc的替代方案。此外，通过一系列进一步的转化，证明了产物的合成价值，并在控制实验的基础上提出了反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-Catalyzed Dienylation of Aldehydes Using Propargylic Carbonates

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Copper-Catalyzed Dienylation of Aldehydes Using Propargylic Carbonates

A copper-catalyzed dienylation of aldehydes using propargylic carbonates in the presence of B₂pin₂ has been successfully developed, enabling the synthesis of a diverse range of substituted 1,3-butadienyl-2-carbinols (BDCs). This innovative approach circumvents the requirement of allene reagents and provides an alternative protocol that allows access to BDCs. In addition, the synthetic value of the products has been demonstrated in a series of further conversions, and the reaction mechanism has been proposed based on control experiments.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.