镍催化C-C键活化苯并环丁酮和降冰片二烯的立体选择性[2 + 2 + 2]环加成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-16 DOI:10.1021/acs.orglett.5c0132410.1021/acs.orglett.5c01324

Robert C. Richter, Ivo H. Lindenmaier, David Schray, Markus Ströbele and Ivana Fleischer*,

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引用次数: 0

摘要

我们报道了镍催化下冰片二烯和苯并环丁酮之间通过C-C活化的立体选择性[2 + 2 + 2]环加成反应。这种转变产生了四个立体中心，产生了引入三维结构的去三环支架。反应以高立体选择性进行，同时允许对反应位点进行精确的立体控制，为构建复杂的立体化学框架提供了一种通用的方法。

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Stereoselective [2 + 2 + 2] Cycloaddition of Benzocyclobutanones and Norbornadienes through Nickel-Catalyzed C–C Bond Activation

We report a nickel-catalyzed stereoselective [2 + 2 + 2] cycloaddition between norbornadienes and benzocyclobutanones via C–C activation. This transformation generates four stereocenters, producing nortricyclane scaffolds that introduce three-dimensional architecture. The reaction proceeds with high stereoselectivity while allowing precise steric control of the reaction site, offering a versatile approach for constructing intricate stereochemical frameworks.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.