顺式木苷和木苷的正式全合成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-19 DOI:10.1021/acs.orglett.5c0150110.1021/acs.orglett.5c01501

Soumyadip Dey, and , Kavirayani R. Prasad*,

引用次数: 0

摘要

以c2对称呋喃醇为原料，正式合成了樟科乙酰原素天然产物顺式-木苷和木苷。合成中的关键反应是呋喃作为丁-2-烯-1,4-二酮的合成，锇催化合成2,5-顺式取代四氢呋喃的Donohoe变体，以及Mukaiyama氧化环化生成反式-2,5-二取代四氢呋喃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Formal Total Synthesis of cis-Sylvaticin and Sylvaticin

查看原文本刊更多论文

Formal Total Synthesis of cis-Sylvaticin and Sylvaticin

Formal total synthesis of Annonaceae acetogenin natural products cis-sylvaticin and sylvaticin was accomplished from a C₂-symmetric furyl carbinol. The key reaction in the synthesis is the use of furan as a but-2-ene-1,4-dione synthon, a Donohoe variant of osmium-catalyzed synthesis of 2,5-cis-substituted tetrahydrofuran, and a Mukaiyama oxidative cyclization for the formation of trans-2,5-disubstitued tetrahydrofuran.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.