Analysis of quality of life and economic burden in patients with chronic urticaria: a comparative study of spontaneous and induced urticaria and its effects on cognition of biologics.

Objective: To compare and analyze the quality of life, economic burden, and knowledge about biological agents between chronic spontaneous urticaria (CSU) and chronic induced urticaria (ClndU), and to provide a reference for clinical rational drug use and patient classification management.

Methods: This cross-sectional multicenter study involved 386 chronic urticaria (CU) patients from three hospitals in various regions, seen between November 2024 and April 2025. Data on demographics, clinical characteristics, Dermatological Quality of Life Index (DLQI), economic burden, and knowledge about biological agents were collected.

Results: 228 CSU patients and 158 CIndU patients. CSU patients had higher DLQI score than CIndU patients (p < .05). CU type, comorbidities, and urticaria control test score were identified as factors affecting the quality of life of CU patients. CSU patients had higher outpatient costs compared to CIndU patients (p < .05). CU type, insurance type, comorbidities, and disease duration were factors influencing outpatient costs. CSU patients exhibited better understanding of relapse and complete remission compared to CIndU patients (p < .05).

Conclusion: Notable differences exist between CSU and CIndU patients in terms of quality of life, economic impact, and knowledge about biological agents. Therefore, it is necessary to categorize these patients to enhance their understanding and utilization of biological agents.