GLP-1 Weight Loss Protocol: An Evidence-Based Translation Project.

Background: Obesity is a prevalent chronic disease associated with many comorbidities and increased mortality rates. Primary care providers are critical in addressing obesity through an evidence-based weight loss protocol. Objective: This Doctor of Nurse Practice project aimed to develop and implement a standardized, evidence-based holistic weight loss protocol, incorporating glucagon-like peptide-1 (GLP-1) medication, semaglutide, and motivational interviewing within a patient-centered framework. Methods: In this quality improvement project, 10 nondiabetic participants with a body mass index (BMI) ≥ 27 kg/m² were recruited from a suburban clinic in Cypress, TX. Data such as body weight, BMI, and blood pressure were collected in addition to Impact of Weight on Quality of Life-Lite (IWQOL-lite) survey responses. Data were then analyzed in Excel using the paired t test with statistical significance being <.05. Results: Participants lost a significant amount of weight (p < .05) and had a significant decrease in BMI (p < .05). Postintervention physical function, self-esteem, and work-related experiences improved significantly (p < .05) based on the IWQOL questionnaire pre- and postintervention. Diastolic blood pressure also significantly decreased (p < .05). Conclusions: This weight loss protocol, guided by evidence-based practice alongside GLP-1 medication, semaglutide, revealed positive outcomes in weight reduction, BMI, and quality of life. This protocol offers providers a promising approach to managing obesity in primary care settings. Implications for Nursing: Implementing this evidence-based weight loss protocol can empower advanced practice nurses (APRNs) to address obesity effectively. Motivational interviewing, holistic patient-centered care, ongoing support, and education are critical features to sustaining weight loss for obese patients. This protocol provides a structured approach for APRNs in guiding nondiabetic overweight and obese patients toward sustainable weight loss.