腹膜后脂肪肉瘤首次复发的预后因素及治疗方式。

IF 2.8 3区 医学 Q3 ONCOLOGY
Yoshiyuki Matsui, Shintaro Iwata, Konosuke Moritani, Aiko Maejima, Satoshi Nara, Yukinori Yamagata, Motokiyo Komiyama, Satoshi Kamio, Kan Yonemori, Akira Kawai, Hiroyuki Fujimoto
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引用次数: 0

摘要

背景:本研究旨在确定腹膜后脂肪肉瘤(LPS)首次复发的预后因素和治疗模式。方法:回顾150例原发性腹膜后脂多糖切除术患者的病历。回顾性分析94例局部或远处复发患者的预后因素及治疗方法。结果:复发时,手术41例,放疗12例,化疗23例,积极监测12例,最佳支持治疗6例。在单变量分析中,与去分化肿瘤相比,分化良好的原发肿瘤预测更好的总生存期(OS) (p = 0.004)。相反,初始手术后较短的无复发生存期(RFS)、治疗时较小的复发肿瘤和复发时较高的中性粒细胞与淋巴细胞比率(NLR)与较差的OS相关(p分别= 0.0418、0.007和0.0475)。治疗决定受RFS、从复发到治疗的时间、初始肿瘤分化、复发部位和多重性的影响。在手术治疗复发的患者中,29.2%(12/41)出现肿瘤分化改变。RFS是这一变化的显著预测因子(p = 0.026)。此外,复发时NLR和从复发到治疗的等待时间是手术治疗患者的重要预后因素(p = 0.005和0.028)。结论:RFS、治疗时间、肿瘤初始分化和复发特征影响首次复发时的治疗选择。RFS可以预测肿瘤分化的变化,而复发时NLR和从复发到治疗的等待时间是手术患者重要的预后指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The prognostic factors and treatment patterns of the first recurrence of retroperitoneal liposarcoma.

Background: This study aimed to identify prognostic factors and treatment patterns at the first recurrence of retroperitoneal liposarcoma (LPS).

Methods: Medical records of 150 patients who underwent resection for primary retroperitoneal LPS were reviewed. Of the 94 patients with local or distant recurrence, prognostic factors and treatment approaches were retrospectively analyzed.

Results: At recurrence, 41 patients underwent surgery, 12 received radiation, 23 received chemotherapy, 12 were under active surveillance, and 6 received best supportive care. In univariate analysis, well-differentiated primary tumors predicted better overall survival (OS) compared to dedifferentiated tumors (p = 0.004). Conversely, shorter recurrence-free survival (RFS) after initial surgery, smaller recurrent tumors at treatment, and high neutrophil-to-lymphocyte ratio (NLR) at recurrence were associated with poorer OS (p = 0.0418, 0.007, and 0.0475, respectively). Treatment decisions were influenced by RFS, time from recurrence to treatment, initial tumor differentiation, recurrence site, and multiplicity. Among those who had surgery for recurrence, 29.2% (12/41) showed a change in tumor differentiation. RFS was a significant predictor of this change (p = 0.026). Additionally, NLR at recurrence and the waiting period from recurrence to treatment were significant prognostic factors in surgically treated patients (p = 0.005 and 0.028, respectively).

Conclusions: RFS, timing of treatment, initial tumor differentiation, and recurrence characteristics influence treatment choices at first recurrence. RFS may predict changes in tumor differentiation, while NLR at recurrence and the waiting period from recurrence to treatment are important prognostic indicators in patients undergoing surgery.

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来源期刊
CiteScore
6.80
自引率
3.00%
发文量
175
审稿时长
2 months
期刊介绍: The International Journal of Clinical Oncology (IJCO) welcomes original research papers on all aspects of clinical oncology that report the results of novel and timely investigations. Reports on clinical trials are encouraged. Experimental studies will also be accepted if they have obvious relevance to clinical oncology. Membership in the Japan Society of Clinical Oncology is not a prerequisite for submission to the journal. Papers are received on the understanding that: their contents have not been published in whole or in part elsewhere; that they are subject to peer review by at least two referees and the Editors, and to editorial revision of the language and contents; and that the Editors are responsible for their acceptance, rejection, and order of publication.
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