IL-33在乳腺癌免疫治疗中的作用：靶点和信号通路

IF 1.2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

European cytokine network Pub Date : 2025-03-01 DOI:10.1684/ecn.2025.0500

Fu Zhang, Miao Lin, Yuancong Jiang, Fangjian Zhou

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引用次数: 0

摘要

白细胞介素-33 （IL-33）是IL-1家族的关键成员，在炎症和癌症中起着重要作用。其经典受体ST2和IL-1受体辅助蛋白（IL-1RAcP）主要在T辅助2 （Th2）细胞和肥大细胞等免疫细胞中表达。最近的研究强调了IL-33在乳腺癌中的参与，证明了它通过调节肿瘤微环境中的先天和适应性免疫反应来发挥双重功能作用的能力。然而，将IL-33与乳腺癌发病机制联系起来的精确分子机制及其作为分子靶向治疗靶点的潜力仍不完全清楚。本文旨在全面总结目前对IL-33在乳腺癌免疫治疗中的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of IL-33 in immunotherapy for breast cancer: targets and signalling pathways.

Interleukin-33 (IL-33), a key member of the IL-1 family, plays a significant role in inflammation and cancer. Its classic receptors, ST2 and IL-1 receptor accessory protein (IL-1RAcP), are predominantly expressed in immune cells such as T helper 2 (Th2) cells and mast cells. Recent studies have highlighted the involvement of IL-33 in breast cancer, demonstrating its ability to exert dual functional effects by modulating both innate and adaptive immune responses within the tumour microenvironment. However, the precise molecular mechanisms linking IL-33 to breast cancer pathogenesis and its potential as a target for molecularly targeted therapies remain incompletely understood. This review aims to provide a comprehensive summary of the current understanding of IL-33 in breast cancer immunotherapy.

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来源期刊

European cytokine network 生物-免疫学

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The journal that brings together all areas of work involving cytokines. European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field. The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation. The journal is referenced in several databases, including Medline, which is testament to its scientific quality.