代谢和营养紊乱对非小细胞肺癌放疗和免疫治疗协同作用的影响。

IF 3.4 2区 医学 Q2 ONCOLOGY
Haiyan Chen, Yaner Yu, Shuangqiu Zhu, Jian Zhao, Yan Ma, Zhifei Huang, Hao Jiang, Qichun Wei
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引用次数: 0

摘要

背景:据报道,患者的代谢和营养状况是抗癌治疗的预后或预测性生物标志物,但很少有人关注其与放疗(RT)和免疫检查点抑制剂(ICIs)的协同作用的关联。方法:2018年至2023年期间同时接受RT和ICIs治疗的转移性非小细胞肺癌(mNSCLC)患者纳入本研究。此外,我们还招募了单独使用ICIs治疗的小细胞肺癌患者,以证实RT和ICIs的协同作用。收集临床病理、代谢和营养因素,分析其对无进展生存期(PFS)、总生存期和体外控制时间的影响。使用腹部CT获取身体组成数据,包括腹部肥胖和肌肉质量。结果:共纳入96例接受RT同时接受ICIs治疗的mNSCLC患者,与单独接受ICIs治疗的患者相比,观察到显著改善PFS的协同效应。在同时接受RT和ICIs的患者中,总脂肪面积(HR = 2.81,P = 0.029)和预后营养指数(HR = 0.24, P)的差异均有统计学意义。结论:代谢和营养状况,特别是体成分和营养指数的综合评估,可作为预测RT和ICIs协同疗效的重要指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of metabolic and nutritional disorders on the synergy between radiotherapy and immunotherapy in non-small-cell lung cancer.

Background: Patient conditions including metabolic and nutritional status were reported to be prognostic or predictive biomarkers of anti-cancer treatment, while little attention has been paid to its association with the synergistic effect of radiotherapy (RT) and immune checkpoint inhibitors (ICIs).

Methods: Metastatic non-small-cell lung cancer (mNSCLC) patients who received concurrent RT and ICIs between 2018 and 2023 were included in this study. In addition, mNSCLC patients treated with ICIs alone were enrolled to confirm the synergetic effect of RT and ICIs. Clinicopathological, metabolic and nutritional factors were collected to analyze their influence on progression-free survival (PFS), overall survival and abscopal control time. Abdominal CT was used to obtain body composition data including abdominal obesity and muscle mass.

Results: A total of 96 mNSCLC patients who received RT concurrent with ICIs were included, and a synergistic effect of significantly improved PFS was observed when compared with patients treated with ICIs alone. Among patients undergoing concurrent RT and ICIs, both total adipose area(HR = 2.81,P = 0.029) and prognosis nutritional index (HR = 0.24, P<0.001) were confirmed as independent positive prognostic markers for PFS. Later-line of immunotherapy (HR = 3.67, P = 0.006), low visceral-to-subcutaneous ratio (VSR, HR = 5.53, P = 0.002), high total adipose area (HR = 5.21, P = 0.0016) and high prognostic nutritional index (HR = 0.24, P = 0.002) were independent risk factors for abscopal progression. Then, we established a scoring system consisting of metabolic and nutritional factors to stratify patients into three groups. Patients with non-visceral obesity and good nutrition status have the longest PFS and abscopal control survival, while patients with poor nutritional status regardless of body composition represent the worst prognosis.

Conclusion: Metabolic and nutritional status, particularly the combined assessment of body composition and nutritional index, serves as a valuable predictor for the synergistic efficacy of concurrent RT and ICIs.

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来源期刊
BMC Cancer
BMC Cancer 医学-肿瘤学
CiteScore
6.00
自引率
2.60%
发文量
1204
审稿时长
6.8 months
期刊介绍: BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.
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