混淆血型抗体在产科：重点对胎儿和新生儿溶血疾病的风险。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2025-05-27 DOI:10.1055/a-2622-2841

Douglas Blackall, Mark Tomlinson

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引用次数: 0

摘要

在常规产前抗体筛查中，有时检测到母体的反应性，其临床意义尚不清楚。因此，在怀孕期间监测这些抗体以减轻胎儿和新生儿溶血病（hdn）风险的策略可能不确定。本文综述了产科中4种免疫反应：抗g、抗m、热反应性自身抗体和不能进一步分类的明显非特异性免疫反应。这些抗体与HDFN的关系是一个主要焦点。相关的问题，包括产妇和新生儿输血的考虑和候选Rh免疫球蛋白，也解决了。

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Confusing blood group antibodies in obstetrics: focus on the risk of hemolytic disease of the fetus and newborn.

During routine prenatal antibody screening, maternal reactivity is sometimes detected for which the clinical significance is unclear. As a result, the strategy for monitoring these antibodies during pregnancy, to mitigate the risk of hemolytic disease of the fetus and newborn (HDFN), may be uncertain. This review focuses on 4 such immune responses in obstetrics: anti-G, anti-M, warm reactive autoantibodies, and apparent non-specific immune responses that cannot be further classified. The relationship of these antibodies to HDFN is a primary focus. Related concerns, including maternal and neonatal transfusion considerations and candidacy for Rh immune globulin, are also addressed.

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.