Jingchi Jiang , Rujia Shen , Yang Yang , Boran Wang , Yi Guan
{"title":"基于可逆神经网络的血糖控制的双向推理方法","authors":"Jingchi Jiang , Rujia Shen , Yang Yang , Boran Wang , Yi Guan","doi":"10.1016/j.cmpb.2025.108844","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Objective</h3><div>: Despite the profound advancements that deep learning models have achieved across a multitude of domains, their propensity to learn spurious correlations significantly impedes their applicability to tasks necessitating causal and counterfactual reasoning.</div></div><div><h3>Methods:</h3><div>In this paper, we propose a Bidirectional Neural Network, which innovatively consolidates forward causal reasoning with inverse counterfactual reasoning into a cohesive framework. This integration is facilitated through the implementation of multi-stacked affine coupling layers, which ensure the network’s invertibility, thereby enabling bidirectional reasoning capabilities within a singular architectural construct. To augment the network’s trainability and to ensure the bidirectional differentiability of the parameters, we introduce an orthogonal weight normalization technique. Additionally, the counterfactual reasoning capacity of the Bidirectional Neural Network is embedded within the policy function of reinforcement learning, thereby effectively addressing the challenges associated with reward sparsity in the blood glucose control scenario.</div></div><div><h3>Results:</h3><div>We evaluate our framework on two pivotal tasks: causal-based blood glucose forecasting and counterfactual-based blood glucose control. The empirical results affirm that our model not only exemplifies enhanced generalization in causal reasoning but also significantly surpasses comparative models in handling out-of-distribution data. Furthermore, in blood glucose control tasks, the integration of counterfactual reasoning markedly improves decision efficacy, sample efficiency, and convergence velocity.</div></div><div><h3>Conclusion:</h3><div>It is our expectation that the Bidirectional Neural Network will pave novel pathways in the exploration of causal and counterfactual reasoning, thus providing groundbreaking methods for complex decision-making processes. Code is available at <span><span>https://github.com/HITshenrj/BNN</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":"269 ","pages":"Article 108844"},"PeriodicalIF":4.9000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A bidirectional reasoning approach for blood glucose control via invertible neural networks\",\"authors\":\"Jingchi Jiang , Rujia Shen , Yang Yang , Boran Wang , Yi Guan\",\"doi\":\"10.1016/j.cmpb.2025.108844\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Objective</h3><div>: Despite the profound advancements that deep learning models have achieved across a multitude of domains, their propensity to learn spurious correlations significantly impedes their applicability to tasks necessitating causal and counterfactual reasoning.</div></div><div><h3>Methods:</h3><div>In this paper, we propose a Bidirectional Neural Network, which innovatively consolidates forward causal reasoning with inverse counterfactual reasoning into a cohesive framework. This integration is facilitated through the implementation of multi-stacked affine coupling layers, which ensure the network’s invertibility, thereby enabling bidirectional reasoning capabilities within a singular architectural construct. To augment the network’s trainability and to ensure the bidirectional differentiability of the parameters, we introduce an orthogonal weight normalization technique. Additionally, the counterfactual reasoning capacity of the Bidirectional Neural Network is embedded within the policy function of reinforcement learning, thereby effectively addressing the challenges associated with reward sparsity in the blood glucose control scenario.</div></div><div><h3>Results:</h3><div>We evaluate our framework on two pivotal tasks: causal-based blood glucose forecasting and counterfactual-based blood glucose control. The empirical results affirm that our model not only exemplifies enhanced generalization in causal reasoning but also significantly surpasses comparative models in handling out-of-distribution data. Furthermore, in blood glucose control tasks, the integration of counterfactual reasoning markedly improves decision efficacy, sample efficiency, and convergence velocity.</div></div><div><h3>Conclusion:</h3><div>It is our expectation that the Bidirectional Neural Network will pave novel pathways in the exploration of causal and counterfactual reasoning, thus providing groundbreaking methods for complex decision-making processes. Code is available at <span><span>https://github.com/HITshenrj/BNN</span><svg><path></path></svg></span>.</div></div>\",\"PeriodicalId\":10624,\"journal\":{\"name\":\"Computer methods and programs in biomedicine\",\"volume\":\"269 \",\"pages\":\"Article 108844\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer methods and programs in biomedicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169260725002615\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260725002615","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
A bidirectional reasoning approach for blood glucose control via invertible neural networks
Background and Objective
: Despite the profound advancements that deep learning models have achieved across a multitude of domains, their propensity to learn spurious correlations significantly impedes their applicability to tasks necessitating causal and counterfactual reasoning.
Methods:
In this paper, we propose a Bidirectional Neural Network, which innovatively consolidates forward causal reasoning with inverse counterfactual reasoning into a cohesive framework. This integration is facilitated through the implementation of multi-stacked affine coupling layers, which ensure the network’s invertibility, thereby enabling bidirectional reasoning capabilities within a singular architectural construct. To augment the network’s trainability and to ensure the bidirectional differentiability of the parameters, we introduce an orthogonal weight normalization technique. Additionally, the counterfactual reasoning capacity of the Bidirectional Neural Network is embedded within the policy function of reinforcement learning, thereby effectively addressing the challenges associated with reward sparsity in the blood glucose control scenario.
Results:
We evaluate our framework on two pivotal tasks: causal-based blood glucose forecasting and counterfactual-based blood glucose control. The empirical results affirm that our model not only exemplifies enhanced generalization in causal reasoning but also significantly surpasses comparative models in handling out-of-distribution data. Furthermore, in blood glucose control tasks, the integration of counterfactual reasoning markedly improves decision efficacy, sample efficiency, and convergence velocity.
Conclusion:
It is our expectation that the Bidirectional Neural Network will pave novel pathways in the exploration of causal and counterfactual reasoning, thus providing groundbreaking methods for complex decision-making processes. Code is available at https://github.com/HITshenrj/BNN.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.