编辑评论:同种异体骨软骨移植的结果在更长时间的随访中是持久的,需要更大的队列和强大的研究设计来帮助我们改善结果。

IF 4.4 1区 医学 Q1 ORTHOPEDICS
Jelle P van der List, David C Flanigan
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引用次数: 0

摘要

软骨和骨软骨病变患者通常表现为衰弱症状,有几种治疗方法,从微骨折和自体软骨细胞植入到自体骨软骨移植和异体骨软骨移植(OCA)。在过去的二十年里,OCA的适应症、移植物储存和手术结果都有了显著的改善,患者报告的结果很好,恢复运动的比率也很可靠。长期研究确定移植物失败的危险因素或令人失望的主观结果对进一步了解理想的OCA候选者很重要。研究发现,冠状动脉排列不整、韧带不稳、半月板功能不全、体重指数较高、年龄较大、症状持续时间较长是导致手术失败的危险因素,为了提高成功率,OCA患者通常会进行相应的伴随手术。未来需要更大规模的研究来进一步确定成功的预测因素,最好是更大的队列,其中混杂因素和其他因素可以被解释和纠正。OCA仍然是骨软骨病变的一种很好的治疗方法,长期随访结果持久。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Editorial Commentary: Osteochondral Allograft Outcomes Are Durable at Longer Follow-Up.

Patients with chondral and osteochondral lesions often present with debilitating symptoms. Several treatments are available, ranging from microfracture and autologous chondrocyte implantation to osteochondral autograft and osteochondral allograft transplantation (OCA). Over the last 2 decades, significant improvement in the indications, graft storage and surgical outcomes of OCA have been seen with excellent patient-reported outcome measures and reliable return-to-sports rates. Long-term studies identifying risk factors for graft failure or disappointing subjective outcomes are important to further understand the ideal candidate for OCA. Studies have identified coronal malalignment, ligament instability, meniscal insufficiency, higher body mass index, older age, and longer duration of symptoms as risk factors for failure, and corresponding concomitant procedures often are performed with OCA to improve success rates. Future larger studies are needed to further identify predictors of success, preferably larger cohorts in which confounders and other factors can be accounted and corrected for. OCA remains an excellent treatment for osteochondral lesions with durable outcomes at long-term follow-up.

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来源期刊
CiteScore
9.30
自引率
17.00%
发文量
555
审稿时长
58 days
期刊介绍: Nowhere is minimally invasive surgery explained better than in Arthroscopy, the leading peer-reviewed journal in the field. Every issue enables you to put into perspective the usefulness of the various emerging arthroscopic techniques. The advantages and disadvantages of these methods -- along with their applications in various situations -- are discussed in relation to their efficiency, efficacy and cost benefit. As a special incentive, paid subscribers also receive access to the journal expanded website.
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