长期使用氯氮平后粒细胞缺乏症1例。

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Agostina Secchi, Madelaine Bridges, Eromona Whiskey, Sukhi Shergill
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引用次数: 0

摘要

中性粒细胞减少症和更严重的、可能危及生命的粒细胞缺乏症是氯氮平公认的副作用,需要定期、强制性和终身血液监测。然而,大多数血液学不良反应发生在治疗的头几个月;因此,现在越来越多的人要求在这一初始阶段之后终止强制性监测。在这个报告中,我们提出了一个难治性精神分裂症患者,他成功地用氯氮平治疗,但在9年后出现了中性粒细胞减少症。这很快演变为粒细胞缺乏症,需要使用粒细胞集落刺激因子和最终停止氯氮平。这种晚发性粒细胞缺乏症病例是孤立和罕见的,但不应妨碍放松强制性氯氮平血液学监测,但患者和护理人员必须意识到粒细胞缺乏症的潜在症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Agranulocytosis after long-term clozapine use: a case report.

Neutropenia and the more severe, potentially life-threatening agranulocytosis are recognized side effects of clozapine that require regular, mandatory, and life-long blood monitoring. However, most cases of haematological adverse effects occur in the first few months of treatment; therefore, there are now increasing calls for the termination of the mandatory monitoring after this initial period. In this report, we present a patient with treatment-resistant schizophrenia who was successfully treated with clozapine yet developed neutropenia after 9 years. This soon evolved into agranulocytosis requiring the use of granulocyte colony-stimulating factor and eventual clozapine cessation. Such late-onset cases of agranulocytosis are isolated and rare but should not impede the drive to relax mandatory clozapine haematological monitoring, but patients and carers must be aware of potential symptoms of agranulocytosis.

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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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