GLP-1激动剂用于儿童精神药理学：机会和注意事项

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Cts-Clinical and Translational Science Pub Date : 2025-05-28 DOI:10.1111/cts.70262

Michael Bartkoski, Ethan A. Poweleit, Stephani L. Stancil

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引用次数: 0

摘要

胰高血糖素样肽-1激动剂（GLP-1A）越来越多地被用于治疗儿童和青少年的肥胖和2型糖尿病。新出现的证据表明，神经精神作用为儿童精神药理学提供了机会，但需要仔细考虑潜在的副作用和滥用风险。这一观点探讨了glp - 1a在儿童心理健康方面的潜在应用和注意事项，特别是药物使用、抑郁症和饮食失调，并主张进行研究和临床监测，以确保其安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

GLP-1 Agonists for Pediatric Psychopharmacology: Opportunities and Cautions

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GLP-1 Agonists for Pediatric Psychopharmacology: Opportunities and Cautions

Glucagon-like peptide-1 agonists (GLP-1A) are increasingly prescribed to treat obesity and type 2 diabetes mellitus in children and adolescents. Emerging evidence suggesting neuropsychiatric effects presents an opportunity for pediatric psychopharmacology but requires careful consideration of potential adverse effects and risk of misuse. This perspective examines potential applications and cautions surrounding GLP-1As for pediatric mental health, particularly substance use, depression, and eating disorders, and advocates for research and clinical monitoring to ensure their safety and efficacy.

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来源期刊

Cts-Clinical and Translational Science 医学-医学：研究与实验

CiteScore

6.70

自引率

2.60%

发文量

234

审稿时长

6-12 weeks

期刊介绍： Clinical and Translational Science (CTS), an official journal of the American Society for Clinical Pharmacology and Therapeutics, highlights original translational medicine research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease. Translational medicine is a multi-faceted discipline with a focus on translational therapeutics. In a broad sense, translational medicine bridges across the discovery, development, regulation, and utilization spectrum. Research may appear as Full Articles, Brief Reports, Commentaries, Phase Forwards (clinical trials), Reviews, or Tutorials. CTS also includes invited didactic content that covers the connections between clinical pharmacology and translational medicine. Best-in-class methodologies and best practices are also welcomed as Tutorials. These additional features provide context for research articles and facilitate understanding for a wide array of individuals interested in clinical and translational science. CTS welcomes high quality, scientifically sound, original manuscripts focused on clinical pharmacology and translational science, including animal, in vitro, in silico, and clinical studies supporting the breadth of drug discovery, development, regulation and clinical use of both traditional drugs and innovative modalities.