{"title":"孟德尔随机化和研究","authors":"Anthony Lockett","doi":"10.1016/j.mpmed.2025.03.009","DOIUrl":null,"url":null,"abstract":"<div><div>Mendelian randomization is an analytical method that uses genetic variants to overcome the confounding factors of observational studies. For Mendelian randomization analysis to be valid, several assumptions must be true: that genetic variants are associated with exposure; that there is no confounding relationship between the variant and the outcome; and that there are no effects of the variant independent of the outcome. Assuming these assumption are met, Mendelian randomization is a valuable tool in determining causality.</div></div>","PeriodicalId":74157,"journal":{"name":"Medicine (Abingdon, England : UK ed.)","volume":"53 6","pages":"Pages 361-363"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mendelian randomization and studies\",\"authors\":\"Anthony Lockett\",\"doi\":\"10.1016/j.mpmed.2025.03.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Mendelian randomization is an analytical method that uses genetic variants to overcome the confounding factors of observational studies. For Mendelian randomization analysis to be valid, several assumptions must be true: that genetic variants are associated with exposure; that there is no confounding relationship between the variant and the outcome; and that there are no effects of the variant independent of the outcome. Assuming these assumption are met, Mendelian randomization is a valuable tool in determining causality.</div></div>\",\"PeriodicalId\":74157,\"journal\":{\"name\":\"Medicine (Abingdon, England : UK ed.)\",\"volume\":\"53 6\",\"pages\":\"Pages 361-363\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine (Abingdon, England : UK ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1357303925000568\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine (Abingdon, England : UK ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357303925000568","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mendelian randomization is an analytical method that uses genetic variants to overcome the confounding factors of observational studies. For Mendelian randomization analysis to be valid, several assumptions must be true: that genetic variants are associated with exposure; that there is no confounding relationship between the variant and the outcome; and that there are no effects of the variant independent of the outcome. Assuming these assumption are met, Mendelian randomization is a valuable tool in determining causality.
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