1,1-二氰环丙烷的合成及亲核开环：从烯烃获得β-氨基羰基衍生物。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-27 DOI:10.1021/acs.orglett.5c00395

Sebastian Govaerts,Jan Lukas Mayer-Figge,Mohit Chotia,Stefan F Kirsch,Adrián Gómez-Suárez

引用次数: 0

摘要

我们报道了1,1-二氰环丙烷亲电试剂的原子转移自由基加成-闭环序列，并证明了它们在温和条件下与烷基胺的亲核开环。在好氧条件下，在一个锅内将所得的氨基单腈产物转化为络合物β-氨基羰基衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis and Nucleophilic Ring-Opening of 1,1-Dicyanocyclopropanes: Accessing β-Aminocarbonyl Derivatives from Olefins.

We report an atom-transfer radical addition-ring closure sequence for the preparation of 1,1-dicyanocyclopropane electrophiles and demonstrate their nucleophilic ring-opening with alkyl amines under mild conditions. The resulting aminomalononitrile products were converted to complex β-aminocarbonyl derivatives in one pot under aerobic conditions.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.