伴随脉冲场烧蚀的热传递。

IF 1.9 4区数学 Q2 BIOLOGY

Journal of Theoretical Biology Pub Date : 2025-05-22 DOI:10.1016/j.jtbi.2025.112145

Angiolo Farina , Antonio Fasano , Massimo Grimaldi , Fabio Rosso

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引用次数: 0

摘要

脉冲场消融（PFA）是一种实现肺静脉隔离的技术，可替代传统的热消融程序。PFA不是传递或减去热量，而是使用高强度电场的快速脉冲，诱导细胞电穿孔。PFA通常被认为不会影响烧蚀部位周围的温度。然而，在某些情况下，观察到患者食管腔温度不可忽视的升高。在这里，我们建立了一个数学模型，为后一种观察提供理论基础，考虑到最坏的情况。

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Heat delivery accompanying pulsed field ablation

Pulsed Field Ablation (PFA) is a technique to achieve pulmonary vein isolation, alternative to the traditional thermal ablation procedures. Instead of delivering or subtracting heat, PFA uses rapid pulses of a high intensity electric field, inducing cells electroporation. PFA is usually claimed not to influence the temperature in the surroundings of the ablation site. Nevertheless, in some case a non-negligible increase of the patient’s luminal esophageal temperature has been observed. Here we set up a mathematical model to provide a theoretical basis to the latter observation, considering a worst case scenario.

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来源期刊

Journal of Theoretical Biology 生物-生物学

CiteScore

4.20

自引率

5.00%

发文量

218

审稿时长

51 days

期刊介绍： The Journal of Theoretical Biology is the leading forum for theoretical perspectives that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research, including: • Brain and Neuroscience • Cancer Growth and Treatment • Cell Biology • Developmental Biology • Ecology • Evolution • Immunology, • Infectious and non-infectious Diseases, • Mathematical, Computational, Biophysical and Statistical Modeling • Microbiology, Molecular Biology, and Biochemistry • Networks and Complex Systems • Physiology • Pharmacodynamics • Animal Behavior and Game Theory Acceptable papers are those that bear significant importance on the biology per se being presented, and not on the mathematical analysis. Papers that include some data or experimental material bearing on theory will be considered, including those that contain comparative study, statistical data analysis, mathematical proof, computer simulations, experiments, field observations, or even philosophical arguments, which are all methods to support or reject theoretical ideas. However, there should be a concerted effort to make papers intelligible to biologists in the chosen field.