基于数据挖掘方法的肝细胞癌碳离子放疗后预后风险分类新方法。

IF 5.7 2区 医学 Q1 Medicine
Cancer Science Pub Date : 2025-05-25 DOI:10.1111/cas.70079
Kazuhiko Hayashi, Osamu Suzuki, Koji Ichise, Hirofumi Uchida, Makoto Anzai, Azusa Hasegawa, Shinichi Shimizu, Teruki Teshima, Jiro Fujimoto, Kazuhiko Ogawa
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引用次数: 0

摘要

目前尚无预测肝细胞癌碳离子放疗后预后的分类方法报道。本研究旨在利用决策树分析作为数据挖掘方法,建立肝癌碳离子放疗后癌症特异性生存(CSS)的风险分类。在这项单中心回顾性研究中,我们分析了2018年至2022年间连续90例接受碳离子放疗的肝细胞癌患者。肝肿瘤以60 Gy(相对生物效能[RBE])的剂量,分四次照射。如果肿瘤靠近胃肠道,则按60 Gy [RBE]分12次照射。对无进展生存期(PFS)和CSS进行单因素和多因素分析,以评估患者的背景和治疗相关因素。采用决策树分析(DTA)评估在多变量分析中有显著差异的CSS预后因素。所有患者的中位随访时间为32.8个月,幸存者为35.6个月。多因素分析发现,剂量分级和预处理甲胎蛋白值是PFS和CSS的重要预后因素。此外,临床分期、缺乏维生素K诱导的预处理蛋白或拮抗剂ΙΙ值是CSS的重要预后因素。DTA显示患者根据预后可分为低危、高危、中危三组。因此,低、中、高危组的3年CSS发生率分别为100%、73.3%和44.4%。DTA是一种基于肿瘤标志物和临床分期的肝癌碳离子放疗后CSS风险分级的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Method for Prognostic Risk Classification After Carbon-Ion Radiotherapy for Hepatocellular Carcinoma Using Data-Mining Methods.

No classification methods to predict prognosis after carbon-ion radiotherapy for hepatocellular carcinoma have yet been reported. This study aimed to develop risk classification for cancer-specific survival (CSS) after carbon-ion radiotherapy for hepatocellular carcinoma using decision tree analysis as a data-mining method. In this single-center, retrospective study, we analyzed 90 consecutive patients with hepatocellular carcinoma treated with carbon-ion radiotherapy between 2018 and 2022. Liver tumors were irradiated at 60 Gy (relative biological effectiveness [RBE]) in four fractions. If the tumor was close to the gastrointestinal tract, it was irradiated at 60 Gy [RBE] in 12 fractions. Univariate and multivariate analyses of progression-free survival (PFS) and CSS were performed to assess patients' background and treatment-related factors. Decision tree analysis (DTA) was performed to assess prognostic factors for CSS that were significantly different in the multivariate analysis. The median follow-up period was 32.8 months for all patients and 35.6 months for survivors. Multivariate analysis identified dose fractionation and pretreatment alpha-fetoprotein values as significant prognostic factors for PFS and CSS. Moreover, clinical stage and pretreatment protein induced by vitamin K absence or antagonist ΙΙ values were significant prognostic factors for CSS. DTA revealed that the patients could be divided into three groups according to prognosis: low-risk, high-risk, and intermediate-risk. Consequently, the 3-year CSS rates for the low-, intermediate-, and high-risk groups were 100%, 73.3%, and 44.4%, respectively. DTA represents a new method for risk classification for CSS after carbon-ion radiotherapy for hepatocellular carcinoma based on tumor markers and clinical stage.

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来源期刊
Cancer Science
Cancer Science ONCOLOGY-
CiteScore
9.90
自引率
3.50%
发文量
406
审稿时长
17 weeks
期刊介绍: Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.
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