固体核磁共振光谱（qSSNMR）在药物分析中的应用

IF 1.9 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Magnetic Resonance in Chemistry Pub Date : 2025-05-26 DOI:10.1002/mrc.5536

Zhaoxi Zheng, Kang Chen, Yang Liu, Eric J Munson, Yongchao Su

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引用次数: 0

摘要

药物分析对药物开发和质量保证至关重要，确保产品符合严格的安全性和有效性标准。定量固体核磁共振（qSSNMR）已成为一项关键技术，能够精确定量和表征固体药物制剂。这篇小型综述强调了qSSNMR的发展，重点是在检测限、分辨率和高通量能力方面的改进。本文综述了分析复杂药物混合物的技术进展及其应用。虽然广泛采用的挑战仍然存在，但自动化、用户友好软件和协作方面的努力旨在解决这些问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Quantitative Solid-State NMR Spectroscopy (qSSNMR) in Pharmaceutical Analysis.

Pharmaceutical analysis is essential to drug development and quality assurance, ensuring that products meet stringent safety and efficacy standards. Quantitative solid-state NMR (qSSNMR) has become a key technique, enabling precise quantification and characterization of solid drug formulations. This mini-review highlights the evolution of qSSNMR, focusing on improvements in detection limits, resolution, and high-throughput capabilities. This review explores technical advancements and applications for analyzing complex pharmaceutical mixtures. While challenges remain for widespread adoption, efforts in automation, user-friendly software, and collaboration aim to address these.

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来源期刊

Magnetic Resonance in Chemistry 化学-光谱学

CiteScore

4.70

自引率

10.00%

发文量

审稿时长

1 months

期刊介绍： MRC is devoted to the rapid publication of papers which are concerned with the development of magnetic resonance techniques, or in which the application of such techniques plays a pivotal part. Contributions from scientists working in all areas of NMR, ESR and NQR are invited, and papers describing applications in all branches of chemistry, structural biology and materials chemistry are published. The journal is of particular interest not only to scientists working in academic research, but also those working in commercial organisations who need to keep up-to-date with the latest practical applications of magnetic resonance techniques.