胎盘重量和胎重比与胎盘DNA甲基化的关系。

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI:10.1080/17501911.2025.2510190

Suvo Chatterjee, Jing Wu, Marion Ouidir, Katherine L Grantz, Fasil Tekola-Ayele

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引用次数: 0

摘要

目的：探讨胎盘甲基化与胎盘重量（PW）和胎盘胎重比（PFR）之间的关系。胎盘重量和胎重比是胎盘功能与不良妊娠结局和晚年疾病风险相关的标志。方法：我们研究了胎盘表观基因组全甲基化与出生时PW和PFR之间的关系（n = 301）。进一步的测试评估了与PW和PFR相关的胞嘧啶-鸟嘌呤位点（CpGs）的甲基化水平是否与胎盘附近基因的表达相关。结果：在5%的错误发现率（FDR）下，27个CpGs的甲基化与PW相关，其中2个CpGs也与PFR相关。27个CpGs中有4个的甲基化与胎盘附近基因的表达有关，包括LEPR、RPS6KA1和COX5A，这些基因在早期发育、细胞生长和氧化应激中起着已知的作用。鉴定出的CpGs与先前报道的与围产期和成人健康结果（如先兆子痫、早产、肥胖和2型糖尿病）相关的甲基化位点重叠。结论：这些发现揭示了胎盘发育和功能效率的表观遗传学基础，并提示它们在介导胎儿发育和迟发性疾病中的潜在作用。

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Association of placental weight and placental-fetal weight ratio with DNA methylation in placenta.

Aim: To investigate the association between placental methylation and placenta weight (PW) and placental-fetal weight ratio (PFR), which are markers of placental function linked to adverse pregnancy outcomes and risk for diseases in later life.

Methods: We examined the association between placental epigenome-wide methylation and PW and PFR at birth (n = 301). Further tests assessed whether methylation levels of the cytosine-guanine sites (CpGs) linked to PW and PFR are associated with placental expression of nearby genes.

Results: At a 5% false discovery rate (FDR), methylation at 27 CpGs was associated with PW, of which two CpGs were also associated with PFR. Methylation at four of the 27 CpGs was associated with placental expression of nearby genes including LEPR, RPS6KA1, and COX5A which have known roles in early development, cellular growth, and oxidative stress. The identified CpGs overlap with previously reported methylation sites associated with perinatal and adult health outcomes such as preeclampsia, preterm delivery, obesity, and type 2 diabetes.

Conclusions: The findings reveal epigenetic underpinnings of placental development and functional efficiency, and suggest their potential roles in mediating fetal development and late-onset diseases.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.