探索癌症的黄金见解:利用双金属金/银纳米结构从基因到人体的传递。

IF 2.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Misbah Ullah Khan, Humaira Aslam, Jehanzeb Sohail, Ali Umar, Aman Ullah, Hayat Ullah
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引用次数: 0

摘要

与癌症的广泛接触在全球范围内继续增加,这导致了对新治疗方法的深入研究;纳米技术已经成为靶向癌症治疗的关键。在纳米材料的范围内,金/银纳米结构因其独特的理想特性和在诊断和癌症治疗中的潜在作用而变得非常有吸引力。所制备的纳米结构具有良好的生物相容性和光学递归改变,并显著提高了金与银相互结合的治疗效果。本文综述了金/银纳米结构在癌症研究中的分子和系统方面的研究,包括纳米结构对分子遗传途径的影响及其在人体系统给药中的应用。我们解释了一些相关的作用机制,如光热疗法(PTT)和光动力疗法(PDT),以及药物输送系统,它们在提供更有针对性的治疗方法和更少的副作用方面显示出潜在的好处。最新的发展表明,它们具有实时成像和生物标志物识别的前景,正因为如此,它们被视为个体化治疗的工具。然而,仍然存在一些限制:扩大规模、生物安全性和将其带到临床的挑战。因此,这些管理部门有责任克服这些障碍,最大限度地发挥其影响。因此,本文对目前的研究成果进行了简要的综述,并对其发展方向进行了讨论,以支持Au/Ag纳米结构在癌症研究和治疗中的革命性作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures.

Sweeping contact with cancer continues to rise globally, which has led to advanced research on new treatment approaches; nanotechnology has become crucial to targeted cancer therapy. Within the intimate of nanomaterials, Au/Ag nanostructures have emerged as highly attractive because of their distinctive desirable characteristics and their prospective roles in diagnosis as well as cancer therapy. The nanostructures developed revealed remarkable biocompatibility, optically recursive alteration, and magnificently improved therapeutic effects of gold and silver in conjunction with each other. This review addresses the molecular and systemic aspects of Au/Ag nanostructures in cancer research, including the impact of nanostructures on the molecular genetic pathways and their use of systemic administration in the human organism. We explain some of the related mechanisms of action, such as photothermal therapy (PTT), and photodynamic therapy (PDT), as well as the drug delivery systems where they display potential benefits towards offering a more targeted treatment approach with fewer side effects. The latest development has shown that they have the prospect of real-time imaging and biomarker identification, and owing to this they are being viewed as a tool for individualized treatment. However, there are still some limitations: challenges of scaling up, biological safety, and bringing it to the clinic. It is therefore incumbent upon these managements to overcome these hurdles to optimize for their impact. As a result, the current findings are briefly reviewed, and the development directions are discussed to support the revolutionary role of Au/Ag nanostructures in cancer research and therapy.

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来源期刊
Discover. Oncology
Discover. Oncology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
2.40
自引率
9.10%
发文量
122
审稿时长
5 weeks
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