维姆塞替尼：首次批准。

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2025-05-26 DOI:10.1007/s40265-025-02191-z

Arnold Lee

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引用次数: 0

摘要

Vimseltinib （ROMVIMZA™）是一种针对集落刺激因子1受体（CSF1R）的口服激酶抑制剂，由Deciphera制药公司开发。由于CSF1R活性已被确定为腱鞘巨细胞瘤（TGCT）的一个促进因素，针对CSF1R的治疗已被研究。Vimseltinib于2025年2月在美国首次获得批准，用于治疗TGCT，目前正在开发中，用于治疗慢性移植物抗宿主病。本文总结了vimseltinib的发展里程碑，该药物首次被批准用于治疗有症状的TGCT成人患者，手术切除可能会导致功能限制恶化或严重发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vimseltinib: First Approval.

Vimseltinib (ROMVIMZA™) is an orally administered kinase inhibitor that targets colony-stimulating factor 1 receptor (CSF1R), which is being developed by Deciphera Pharmaceuticals. As CSF1R activity has been identified as a contributing factor for tenosynovial giant cell tumour (TGCT), treatments targeting CSF1R have been investigated. Vimseltinib received its first approval in February 2025 in the USA for the treatment of TGCT and is under development for the treatment of chronic graft versus host disease. This article summarizes the milestones in the development of vimseltinib leading to this first approval for the treatment of adult patients with symptomatic TGCT for which surgical resection will potentially cause worsening functional limitation or severe morbidity.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.