Interactions of Micro- and Nanoplastics with Biomolecules: From Public Health to Protein Corona Effect and Beyond.

Micro- and nanoplastics (M/NPs), as ubiquitous global environmental pollutants, have garnered increasing attention due to their pervasive presence. These particles can interact with biological molecules through various mechanisms, subsequently inducing potential toxic effects on living organisms. This review investigates the hazards of M/NPs and their interactions with biological membranes and proteins, focusing on their interaction mechanisms and potential effects on biomolecular structure and function. Specifically, we summarize the exposure pathways and potential harms of M/NPs, which can enter the human body through ingestion, inhalation, and skin contact, potentially causing toxicity, inflammation responses, oxidative stress, and endocrine disruption. Additionally, we highlight the interaction between M/NPs and biological membranes, which can induce structural changes, including membrane thickening, increased fluidity, and pore formation, thereby compromising membrane integrity and affecting cellular health. Besides, we emphasize the interaction between M/NPs and proteins, suggesting that protein structural changes and corona formation can influence oxidative stress responses and cytotoxicity, thereby impacting cellular functions and viability. Ultimately, suggestions and outlooks for further research are proposed. Overall, this review systematically summarizes current research on the interactions between M/NPs and biomolecules, including their mechanisms and biological effects, providing researchers with a comprehensive understanding of the field.