养宠物会增加特应性哮喘儿童呼出的一氧化氮和哮喘严重程度。

IF 4.1 2区 医学 Q2 ALLERGY
Kun-Baek Song, Jeong-Hoon Kim, Eom Ji Choi, Seung Won Lee, Jin Tack Kim, Dae Hyun Lim, Woo Kyung Kim, Dae Jin Song, Young Yoo, Dong In Suh, Hey-Sung Baek, Meeyong Shin, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jinho Yu
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引用次数: 0

摘要

接触宠物会引发对宠物过敏的哮喘儿童的症状。然而,对宠物不敏感的儿童养宠物与哮喘发病率之间的关系知之甚少。我们的目的是研究宠物对哮喘儿童肺功能、气道炎症和发病率的影响,并确定宠物暴露的影响是否因宠物致敏状态而异。共有975名5-15岁的哮喘儿童被纳入韩国儿童哮喘研究。通过问卷调查或儿科医生评估来评估宠物拥有权和哮喘发病率。评估肺功能、呼气一氧化氮分数(FeNO)和特应性状态。养宠物的儿童的FeNO水平明显高于没有宠物的儿童。与宠物致敏状态无关,宠物饲养显著增加了特应性哮喘儿童的FeNO水平。在宠物敏感儿童中,养宠物组的几何平均值为46.6(1个标准差范围,26.9-81.5),而不养宠物组的几何平均值为27.2 (13.8-53.6)(P < 0.001)。在对宠物不敏感的儿童中,宠物主人的几何平均值为37.3(15.0-53.6),而非宠物主人的几何平均值为25.2 (12.9-49.2)(P = 0.014)。多元回归分析还显示,养宠物与异位性哮喘儿童FeNO水平升高和哮喘严重程度显著相关。在患有特应性哮喘的儿童中,饲养宠物增加了FeNO水平和哮喘严重程度,与宠物致敏状态无关。即使是对宠物不敏感的特应性哮喘儿童,接触宠物也会增加气道炎症和疾病的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pet Ownership Increases the Exhaled Nitric Oxide and Asthma Severity in Children With Atopic Asthma.

Exposure to pets can trigger symptoms in asthmatic children sensitized to pets. However, little is known about the association between pet ownership and asthma morbidity in children who are not sensitized to pets. We aimed to investigate the effect of pets on lung function, airway inflammation, and morbidity in children with asthma, and to determine whether the effect of exposure to pets vary based on pet sensitization status. A total of 975 asthmatic children, aged 5-15 years, were enrolled in the Korean Childhood Asthma Study. Pet ownership and asthma morbidity were evaluated by questionnaires or pediatrician evaluations. Pulmonary function, fractional exhaled nitric oxide (FeNO), and atopic status were assessed. FeNO levels were significantly higher in children with pets than in those without pets. Pet ownership significantly increased FeNO levels in atopic asthmatic children, irrespective of pet sensitization status. In children sensitized to pets, the geometric mean was 46.6 (range of 1 standard deviation, 26.9-81.5) for those with pets vs. 27.2 (13.8-53.6) for those without pets (P < 0.001). In children without sensitization to pets, the geometric mean was 37.3 (15.0-53.6) for pet owners vs. 25.2 (12.9-49.2) for non-owners (P = 0.014). The multiple regression analysis also revealed that pet ownership was significantly associated with increased FeNO levels and asthma severity in atopic asthmatic children. Pet ownership increased the FeNO levels and asthma severity, regardless of pet sensitization status, in children with atopic asthma. Exposure to pets could increase airway inflammation and disease severity even in atopic asthmatic children who are not sensitized to pets.

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来源期刊
CiteScore
6.10
自引率
6.80%
发文量
53
审稿时长
>12 weeks
期刊介绍: The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.
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