循环miR-425可能是帕金森病患者抑郁的生物标志物

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Hong Liu , Haonan Zhao , Dongya Huang
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引用次数: 0

摘要

抑郁症是帕金森病(PD)患者的一种常见合并症,但通常未被充分诊断和治疗。循环microrna (miRNAs)已被证明是PD的有希望的生物标志物候选物。然而,目前还没有mirna作为PD患者抑郁的生化标志物。方法采用qPCR检测52名健康对照、69名非抑郁PD患者(PD- nd)和62名抑郁PD患者(PD- d)的血清样本中miR-425的水平。所有参与者都使用详细的临床量表进行评估。结果与PD-ND患者相比,PD-D患者的miR-425 (miR-425)表达下调,受试者工作特征曲线分析的曲线下面积为0.867。miR-425水平与抑郁(HAMD, r = -0.423,p <; 0.001)和焦虑(HAMA, r = -0.469,p <; 0.001)的严重程度呈负相关。此外,PD-D患者在H-Y、MDS-UPDRS (I、II和III)、NMSS(1、3、5和9)、HAMD、HAMA、RBDSQ、ESS和ADL方面的得分高于PD-ND患者,而在NMSS7、MMSE、SS-16和PDQ-39方面的得分低于PD-ND患者。二元logistic回归分析发现,认知障碍(MMSE, p = 0.001)和焦虑(HAMA, p <; 0.001)与PD患者抑郁显著相关。结论循环miR-425作为PD患者抑郁的生物标志物具有显著潜力,在PD- d患者中明显下调,且与抑郁严重程度有很强的相关性。我们的研究结果表明,在改善PD-D诊断和了解其病理生理方面具有独特的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating miR-425 can be a biomarker for depression in patients with Parkinson’s disease

Introduction

Depression, a common comorbidity in patients with Parkinson's disease (PD), is often underdiagnosed and undertreated. Circulating microRNAs (miRNAs) have been proved to be promising biomarker candidates for PD. However, no miRNAs are currently available as biochemical markers of depression in PD.

Method

Serum samples from 52 healthy controls, 69 non-depressed PD patients (PD-ND), and 62 depressed PD patients (PD-D) were analyzed using qPCR to measure miR-425 levels. All the participants were assessed using detailed clinical scales.

Results

miRNA-425 (miR-425) expression in PD-D patients was downregulated compared with that in PD-ND patients, with an area under the curve of 0.867 in receiver operating characteristic curve analysis. miR-425 levels were negatively correlated with the severity of depression (HAMD, r = -0.423, p < 0.001) and anxiety (HAMA, r = -0.469, p < 0.001). Additionally, PD-D patients scored higher in H-Y, MDS-UPDRS (I, II, and III), NMSS (1, 3, 5, and 9), HAMD, HAMA, RBDSQ, ESS, and ADL and lower in NMSS7, MMSE, SS-16, and PDQ-39 than PD-ND patients. Binary logistic regression analysis identified that cognitive impairment (MMSE, p = 0.001) and anxiety (HAMA, p < 0.001) were significantly associated with depression in PD.

Conclusion

Circulating miR-425 shows significant potential as a biomarker for depression in PD, with distinct downregulation in PD-D patients and a strong correlation with depression severity. Our findings suggest a unique potential for improving PD-D diagnosis and understanding its pathophysiology.
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来源期刊
Clinical Neurology and Neurosurgery
Clinical Neurology and Neurosurgery 医学-临床神经学
CiteScore
3.70
自引率
5.30%
发文量
358
审稿时长
46 days
期刊介绍: Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.
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