脑出血中基底节区默认模式网络连接改变：静息状态fMRI研究

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-05-25 DOI:10.1016/j.clineuro.2025.108987

Lichao Wei , Jun Zhang , Fengyuan Zhou , Dewen Ru , Caihua Xi , Zhuoyin Du , Biwu Wu , Gang Wu , Qiang Yuan , Jin Hu

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引用次数: 0

摘要

目的应用静息状态功能磁共振成像（rs-fMRI）研究基底节区脑出血（ICH）对脑默认模式网络（DMN）连通性的影响及其与认知功能障碍的关系。方法分别分析左/右基底节区脑出血患者与健康对照组的ddmn差异。双侧基底节区差异脑区重叠得到共改变脑区。基因和功能解码分析证实了共同改变的大脑区域在认知中的作用。以共改变脑区为种子进行全脑功能连通性（FC）分析，并与Mini-Mental State Examination （MMSE）进行相关性分析，获得基底节区ICH患者的认知表征脑网络。最后将其与基底神经节脑出血患者的DMN进行嵌套，得到基底神经节脑出血患者DMN中调节认知功能的重要脑区。结果共纳入89例基底神经节脑出血患者。与健康对照相比，双侧基底节区脑出血患者DMN连通性有显著改变。共同改变的脑区主要涉及内侧前额叶皮层（mPFC）。此外，基因和功能解码分析显示，与化学突触传递，突触信号，认知和智力密切相关。左侧海马旁回、左侧颞上回、右侧颞区、小脑和后扣带皮层与MMSE呈显著相关。此外，左侧海马旁回是基底神经节ICH患者DMN中参与认知调节的关键节点。结论DMN中mpfc -左侧海马旁回路在基底节区脑出血后的认知调节中起重要作用。这些发现为基底神经节脑出血后认知变化的神经机制提供了新的见解，并为认知康复提供了潜在的治疗靶点。

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Altered default mode network connectivity in basal ganglia intracerebral hemorrhage: A resting-state fMRI study

Objective

This study investigates the impact of basal ganglia intracerebral hemorrhage (ICH) on default mode network (DMN) connectivity and its relationship with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI).

Method

DMN differences between left/right basal ganglia ICH patients and healthy controls were analyzed respectively. Co-altered brain region were obtained by overlapping the differential brain regions of bilateral basal ganglia ICH. Gene and functional decoding analyses validated the role of co-altered brain regions in cognition. Whole-brain functional connectivity (FC) analysis was conducted using the co-altered brain region as a seed, and correlation analysis was performed with the Mini-Mental State Examination (MMSE) to obtain the cognitive representation brain network of patients in basal ganglia ICH. Finally, it was nested with the DMN of basal ganglia ICH patients to obtain the important brain regions regulating cognitive function in the DMN of basal ganglia ICH patients.

Result

A total of 89 basal ganglia ICH patients were enrolled. Compared to healthy controls, bilateral basal ganglia ICH patients showed significant alterations in DMN connectivity. The co-altered brain region mainly involved the medial prefrontal cortex (mPFC). Additionally, gene and functional decoding analyses revealed strong association with chemical synaptic transmission, synaptic signaling, cognition, and intelligence. The left parahippocampal gyrus, the left superior temporal gyrus, right temporal regions, the cerebellar, and posterior cingulate cortex exhibited significant correlation with MMSE. Furthermore, the left parahippocampal gyrus emerged as a key node in the DMN of basal ganglia ICH patients involved in cognitive regulation.

Conclusion

The mPFC-left parahippocampal circuit in the DMN plays a crucial role in cognitive regulation following basal ganglia ICH. These findings provide new insights into neural mechanisms underlying cognitive changes after basal ganglia ICH and suggest potential therapeutic targets for cognitive rehabilitation.

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.