逆转录病毒在肿瘤发生中的协同作用通过蛋白质的加法和协同作用以及抗逆转录病毒治疗的交叉反应性

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2025-05-24 DOI:10.1016/j.mehy.2025.111667

Ante Tomasović

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引用次数: 0

摘要

逆转录病毒在肿瘤发生中的协同作用是通过蛋白质的加法和协同作用提出的，来自不同逆转录因子的功能相似的蛋白质在宿主细胞内的加法和协同作用，增强了所述逆转录因子的总蛋白表达。这反过来增强逆转录病毒致瘤调节蛋白的表达，促进正常细胞转化为癌细胞，增加增殖，抑制细胞凋亡，增强免疫逃避，从而促进癌症的发展和持续存在。抗逆转录病毒治疗的交叉反应性假说提出，抗hiv药物通过抑制癌细胞内活跃的一种或多种逆转录病毒或内源性逆转录因子来发挥抗癌作用。靶向癌细胞中的逆转录酶可以作为一种可行的治疗方法，值得进一步研究。

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Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy

The hypothesis of retroviral synergy in oncogenesis via additive and cooperative protein actions proposes that functionally similar proteins from different retroelements act additive and cooperative within host cells, enhancing the total protein expression of said retroelements. This in turn enhances expression of retroviral tumorigenic regulator proteins which promote transformation of normal cells into cancer cells, increased proliferation, inhibition of apoptosis, and enhanced immune evasion, thereby contributing to both cancer development and its persistence.

The cross-reactivity of antiretroviral therapy hypothesis proposes that anti-HIV drugs exert anticancer effects by inhibiting one or more retroviruses, or endogenous retroelements, that are active within cancer cells.

Targeting retroviral enzymes in cancer cells can serve as a viable therapeutic approach, warranting further investigation.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.