ALSUntangled #79:硫辛酸

IF 2.8
Alaina Giacobbe, James Hiana, Olivia Wang, Michael Benatar, Paul Wicks, Javier Mascias Cadavid, Sartaj Jhooty, Christopher McDermott, Gary Pattee, Tulio Bertorini, Terry Heiman-Patterson, Dylan Ratner, Paul Barkhaus, Gregory Carter, Carlayne Jackson, Keelie Denson, Andrew Brown, Carmel Armon, Yuyao Sun, Andre Nguyen, Richard Bedlack, Xiaoyan Li
{"title":"ALSUntangled #79:硫辛酸","authors":"Alaina Giacobbe, James Hiana, Olivia Wang, Michael Benatar, Paul Wicks, Javier Mascias Cadavid, Sartaj Jhooty, Christopher McDermott, Gary Pattee, Tulio Bertorini, Terry Heiman-Patterson, Dylan Ratner, Paul Barkhaus, Gregory Carter, Carlayne Jackson, Keelie Denson, Andrew Brown, Carmel Armon, Yuyao Sun, Andre Nguyen, Richard Bedlack, Xiaoyan Li","doi":"10.1080/21678421.2025.2507166","DOIUrl":null,"url":null,"abstract":"<p><p>Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression. In ALS preclinical studies, ALA slowed motor function decline and improved survival. There were self-reported cases of improved muscle strength in ALS patients when ALA was taken with numerous additional supplements, making it difficult to discern its efficacy. One small, 6-month open-label study showed improved quality of life, fatigue, and mood after participants took it with B vitamins and amino acids for the first 3 months. So far, no clinical trials have been published in people living with amyotrophic lateral sclerosis (PALS). Given the insufficient clinical data, we cannot endorse ALA and will support more research on its efficacy in slowing ALS progression.</p>","PeriodicalId":72184,"journal":{"name":"Amyotrophic lateral sclerosis & frontotemporal degeneration","volume":" ","pages":"1-5"},"PeriodicalIF":2.8000,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ALSUntangled #79: alpha-lipoic acid.\",\"authors\":\"Alaina Giacobbe, James Hiana, Olivia Wang, Michael Benatar, Paul Wicks, Javier Mascias Cadavid, Sartaj Jhooty, Christopher McDermott, Gary Pattee, Tulio Bertorini, Terry Heiman-Patterson, Dylan Ratner, Paul Barkhaus, Gregory Carter, Carlayne Jackson, Keelie Denson, Andrew Brown, Carmel Armon, Yuyao Sun, Andre Nguyen, Richard Bedlack, Xiaoyan Li\",\"doi\":\"10.1080/21678421.2025.2507166\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression. In ALS preclinical studies, ALA slowed motor function decline and improved survival. There were self-reported cases of improved muscle strength in ALS patients when ALA was taken with numerous additional supplements, making it difficult to discern its efficacy. One small, 6-month open-label study showed improved quality of life, fatigue, and mood after participants took it with B vitamins and amino acids for the first 3 months. So far, no clinical trials have been published in people living with amyotrophic lateral sclerosis (PALS). Given the insufficient clinical data, we cannot endorse ALA and will support more research on its efficacy in slowing ALS progression.</p>\",\"PeriodicalId\":72184,\"journal\":{\"name\":\"Amyotrophic lateral sclerosis & frontotemporal degeneration\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Amyotrophic lateral sclerosis & frontotemporal degeneration\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21678421.2025.2507166\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Amyotrophic lateral sclerosis & frontotemporal degeneration","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21678421.2025.2507166","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

α硫辛酸(ALA)是一种天然存在的脂肪酸。它是线粒体能量产生中酶促反应的重要辅助因子,是一种有效的抗氧化剂,具有抗炎作用,这是减缓ALS进展的合理机制。在ALS临床前研究中,ALA延缓了运动功能衰退,提高了生存率。当ALA与许多其他补充剂一起服用时,ALS患者有自我报告的肌肉力量改善的病例,这使得很难辨别其功效。一项为期6个月的小型开放标签研究显示,参与者在前3个月服用B族维生素和氨基酸后,生活质量、疲劳和情绪都有所改善。到目前为止,还没有发表针对肌萎缩性侧索硬化症(PALS)患者的临床试验。鉴于临床数据不足,我们不能支持ALA,并将支持更多关于其减缓ALS进展的功效的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ALSUntangled #79: alpha-lipoic acid.

Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression. In ALS preclinical studies, ALA slowed motor function decline and improved survival. There were self-reported cases of improved muscle strength in ALS patients when ALA was taken with numerous additional supplements, making it difficult to discern its efficacy. One small, 6-month open-label study showed improved quality of life, fatigue, and mood after participants took it with B vitamins and amino acids for the first 3 months. So far, no clinical trials have been published in people living with amyotrophic lateral sclerosis (PALS). Given the insufficient clinical data, we cannot endorse ALA and will support more research on its efficacy in slowing ALS progression.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信