肠道微生物来源的细胞外囊泡：探讨神经精神疾病的发病机制和治疗

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-05-22 DOI:10.1016/j.lfs.2025.123750

Wenjie Zhu , Yanling Yuan , Xuan Guan , Qinglian Xie , Xueli Sun , Zaiquan Dong

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引用次数: 0

摘要

肠道微生物群与各种神经精神疾病的发病机制有关，包括认知障碍和抑郁症。肠道微生物群可以沿着肠-脑轴通过多种途径作用于大脑。然而，具体机制尚不清楚。细菌胞外囊泡（BEVs）是细菌来源的膜结合囊泡，可以携带多种生物活性物质并穿过宿主体内的各种屏障，被细菌用来与宿主进行交流和相互作用。最近的研究表明，来自肠道微生物群的bev参与肠-脑通讯，并可能在神经精神疾病的发病和治疗中发挥作用。本文综述了bev的生物发生、结构和功能，并强调了它们在神经精神疾病的发展和治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gut microbiota-derived extracellular vesicles: Exploring the pathogenesis and treatment of neuropsychiatric disorders

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Gut microbiota-derived extracellular vesicles: Exploring the pathogenesis and treatment of neuropsychiatric disorders

The gut microbiome is connected to the pathogenesis of various neuropsychiatric disorders, including cognitive impairment and depression. The gut microbiota can act on the brain through multiple pathways along the gut–brain axis. However, the specific mechanisms are unclear. Bacterial extracellular vesicles (BEVs), bacteria-derived membrane-bound vesicles that can carry a variety of bioactive substances and cross various barriers in the host, are used by bacteria to communicate and interact with the host. Recent studies have shown that BEVs from the gut microbiota are involved in gut-brain communication and may play a role in the pathogenesis and treatment of neuropsychiatric disorders. This review provides an overview of the biogenesis, structure, and function of BEVs and emphasizes their role in the development and treatment of neuropsychiatric disorders.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.