CD44和SLC1A2通常受到调节，但在ER+乳腺癌中不形成融合转录物。

IF 3.7 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2025-09-01 Epub Date: 2025-05-23 DOI:10.1007/s11010-025-05308-w

Francesca Bonechi, Marina Bacci, Nicla Lorito, Alfredo Smiriglia, Edoardo Pagliantini, Matteo Benelli, Icro Meattini, Andrea Morandi

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引用次数: 0

摘要

内分泌治疗（ET）对于治疗ER+ HER2-乳腺癌至关重要；然而，耐药性仍然是一个重大的临床挑战。本研究调查了CD44-SLC1A2基因融合在胃肠道恶性肿瘤中是否有助于乳腺癌的ET耐药机制。虽然没有检测到CD44-SLC1A2融合体，但CD44和SLC1A2的高表达与较差的生存结果相关，并确定了一个由天冬氨酸和谷氨酸代谢维持的治疗耐药亚群，突出了未来治疗干预的潜在代谢脆弱性。

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CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer.

Endocrine therapy (ET) is essential for managing ER+ HER2- breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, reported in gastrointestinal malignancies, contribute to ET resistance mechanisms in breast cancer. Although no CD44-SLC1A2 fusions were detected, high expression of CD44 and SLC1A2 was associated with poor survival outcomes and identified a therapy-resistant subpopulation sustained by aspartate and glutamate metabolism, highlighting potential metabolic vulnerabilities for future therapeutic intervention.

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.