父母肝病死亡率与酒精相关性肝炎患者的不良结局相关。

IF 5.6 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Hepatology Communications Pub Date : 2025-05-23 eCollection Date: 2025-06-01 DOI:10.1097/HC9.0000000000000666
Wanzhu Tu, Samer Gawrieh, Lauren Nephew, Craig McClain, Qing Tang, Srinivasan Dasarathy, Vatsalya Vatsalya, Douglas A Simonetto, Carla Kettler, Gyongyi Szabo, Bruce Barton, Yunpeng Yu, Patrick S Kamath, Arun J Sanyal, Laura Nagy, Mack C Mitchell, Suthat Liangpunsakul, Vijay H Shah, Naga Chalasani, Ramon Bataller
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引用次数: 0

摘要

背景:父母酒精使用障碍和肝脏疾病相关死亡率如何影响后代酒精相关性肝炎(AH)的风险和结局尚不清楚。方法:我们分析了两项关于AH病例和重度饮酒对照(HDCs)的前瞻性观察研究的数据。在研究开始时评估父母酒精使用障碍和肝脏疾病死亡率的家族史。采用Logistic回归和Cox比例风险模型评估家族史对AH发展和结局的影响。结果:两个前瞻性队列(926例AH病例和430例HDC病例)的1356名参与者的数据被合并并分析。父母酒精使用障碍在AH病例中占56.9%,在HDC病例中占61.1%;7.5%的AH病例和5.7%的HDC病例报告父母因肝病死亡。多变量logistic回归显示,在控制了人口统计学特征和饮酒行为后,父母肝病相关死亡率与后代患AH的风险增加一倍以上相关(OR=2.26, 95% CI:[1.22, 4.20])。此外,在AH病例中,父母一方死于肝病显著增加了研究参与者在调整其他危险因素影响后的90天死亡率(HR=2.26, 95% CI:[1.05, 4.86])。结论:本研究强调了父母因肝病死亡对AH发展和死亡率的影响。通过家族史确定有AH风险的患者可能有助于促进关于减少饮酒的讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis.

Background: How parental alcohol use disorder and liver disease-related mortality influence the risk and the outcomes of alcohol-associated hepatitis (AH) in the offspring is unknown.

Methods: We analyzed data from 2 prospective observational studies of AH cases and heavy drinking controls (HDCs). Family history of parental alcohol use disorder and liver disease mortality was assessed at the study entry. Logistic regression and Cox proportional hazard models were used to assess the influences of family history on AH development and outcome.

Results: Data from 1356 participants in two prospective cohorts (926 AH cases and 430 HDC) were combined and analyzed. Parental alcohol use disorder was found in 56.9% of AH cases and 61.1% of HDC; parental death due to liver disease was reported in 7.5% of AH cases and 5.7% of HDC. Multivariable logistic regression showed that parental liver disease-related mortality was associated with more than a doubled risk of AH development in the offspring after controlling for their demographic characteristics and drinking behavior (OR=2.26, 95% CI: [1.22, 4.20]). Moreover, among the AH cases, having a parent die of liver disease significantly increased the 90-day mortality of study participants after adjusting for the effects of other risk factors (HR=2.26, 95% CI: [1.05, 4.86]).

Conclusions: The study highlights the influences of parental death due to liver disease on AH development and mortality. Identifying patients at risk of AH through family history might help facilitate discussions on reducing alcohol consumption.

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来源期刊
Hepatology Communications
Hepatology Communications GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
8.00
自引率
2.00%
发文量
248
审稿时长
8 weeks
期刊介绍: Hepatology Communications is a peer-reviewed, online-only, open access journal for fast dissemination of high quality basic, translational, and clinical research in hepatology. Hepatology Communications maintains high standard and rigorous peer review. Because of its open access nature, authors retain the copyright to their works, all articles are immediately available and free to read and share, and it is fully compliant with funder and institutional mandates. The journal is committed to fast publication and author satisfaction. ​
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