Chiara Giraudo, Giulia Fichera, Marco Binda, Beatrice Moccaldi, Elisabetta Cocconcelli, Anna Cuberli, Anna Michielin, Andrea Doria, Roberto Stramare, Elisabetta Balestro, Elisabetta Zanatta
{"title":"身体成分对系统性硬化症患者有影响吗?","authors":"Chiara Giraudo, Giulia Fichera, Marco Binda, Beatrice Moccaldi, Elisabetta Cocconcelli, Anna Cuberli, Anna Michielin, Andrea Doria, Roberto Stramare, Elisabetta Balestro, Elisabetta Zanatta","doi":"10.1093/rheumatology/keaf283","DOIUrl":null,"url":null,"abstract":"Objectives Body composition plays a significant role in various rheumatic and autoinflammatory diseases. The aim of our study was to assess the impact of muscle mass and subcutaneous adipose tissue quality and quantity in patients with systemic sclerosis (SSc). Methods Adults with SSc referring to our tertiary center who underwent high-resolution chest computed tomography (HRCT) to assess pulmonary involvement were included. A semi-automatic segmentation of the subcutaneous fat and paravertebral muscle was performed at the level of the 12th dorsal vertebra, and body composition metrics were collected (subcutaneous fat and paravertebral muscle area and density). Stepwise linear regression analysis was applied to evaluate if body composition, demographics, and pulmonary function tests acted as predictors of mortality. Considering patients with muscle Hu values <30 as affected by myosteatosis, we used the odds-risk ratio to assess if it is associated with a higher risk of mortality. Results Eighty-seven SSc patients (77 females, age 60±15 years, 61% affected by limited cutaneous SSc) were included. The linear model demonstrated that lower DLCO (p = 0.047), higher BMI (p = 0.013), higher density of the subcutaneous fat (p = 0.005), and lower skeletal-muscle index (p < 0.001) acted as predictors of mortality. Overall, 63 patients (72%) were affected by myosteatosis (ie, Hu < 30 Hu) and patients affected by muscle fat infiltration at CT showed a 3.345 times higher mortality risk (95% CI 0.396–28.295). Conclusion Patients with systemic sclerosis are affected by myosteatosis and pre-sarcopenia and body composition seems to influence the overall outcome.","PeriodicalId":21255,"journal":{"name":"Rheumatology","volume":"22 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Does body composition matter in patients with systemic sclerosis?\",\"authors\":\"Chiara Giraudo, Giulia Fichera, Marco Binda, Beatrice Moccaldi, Elisabetta Cocconcelli, Anna Cuberli, Anna Michielin, Andrea Doria, Roberto Stramare, Elisabetta Balestro, Elisabetta Zanatta\",\"doi\":\"10.1093/rheumatology/keaf283\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives Body composition plays a significant role in various rheumatic and autoinflammatory diseases. The aim of our study was to assess the impact of muscle mass and subcutaneous adipose tissue quality and quantity in patients with systemic sclerosis (SSc). Methods Adults with SSc referring to our tertiary center who underwent high-resolution chest computed tomography (HRCT) to assess pulmonary involvement were included. A semi-automatic segmentation of the subcutaneous fat and paravertebral muscle was performed at the level of the 12th dorsal vertebra, and body composition metrics were collected (subcutaneous fat and paravertebral muscle area and density). Stepwise linear regression analysis was applied to evaluate if body composition, demographics, and pulmonary function tests acted as predictors of mortality. Considering patients with muscle Hu values <30 as affected by myosteatosis, we used the odds-risk ratio to assess if it is associated with a higher risk of mortality. Results Eighty-seven SSc patients (77 females, age 60±15 years, 61% affected by limited cutaneous SSc) were included. The linear model demonstrated that lower DLCO (p = 0.047), higher BMI (p = 0.013), higher density of the subcutaneous fat (p = 0.005), and lower skeletal-muscle index (p < 0.001) acted as predictors of mortality. Overall, 63 patients (72%) were affected by myosteatosis (ie, Hu < 30 Hu) and patients affected by muscle fat infiltration at CT showed a 3.345 times higher mortality risk (95% CI 0.396–28.295). Conclusion Patients with systemic sclerosis are affected by myosteatosis and pre-sarcopenia and body composition seems to influence the overall outcome.\",\"PeriodicalId\":21255,\"journal\":{\"name\":\"Rheumatology\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/rheumatology/keaf283\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/rheumatology/keaf283","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Does body composition matter in patients with systemic sclerosis?
Objectives Body composition plays a significant role in various rheumatic and autoinflammatory diseases. The aim of our study was to assess the impact of muscle mass and subcutaneous adipose tissue quality and quantity in patients with systemic sclerosis (SSc). Methods Adults with SSc referring to our tertiary center who underwent high-resolution chest computed tomography (HRCT) to assess pulmonary involvement were included. A semi-automatic segmentation of the subcutaneous fat and paravertebral muscle was performed at the level of the 12th dorsal vertebra, and body composition metrics were collected (subcutaneous fat and paravertebral muscle area and density). Stepwise linear regression analysis was applied to evaluate if body composition, demographics, and pulmonary function tests acted as predictors of mortality. Considering patients with muscle Hu values <30 as affected by myosteatosis, we used the odds-risk ratio to assess if it is associated with a higher risk of mortality. Results Eighty-seven SSc patients (77 females, age 60±15 years, 61% affected by limited cutaneous SSc) were included. The linear model demonstrated that lower DLCO (p = 0.047), higher BMI (p = 0.013), higher density of the subcutaneous fat (p = 0.005), and lower skeletal-muscle index (p < 0.001) acted as predictors of mortality. Overall, 63 patients (72%) were affected by myosteatosis (ie, Hu < 30 Hu) and patients affected by muscle fat infiltration at CT showed a 3.345 times higher mortality risk (95% CI 0.396–28.295). Conclusion Patients with systemic sclerosis are affected by myosteatosis and pre-sarcopenia and body composition seems to influence the overall outcome.
期刊介绍:
Rheumatology strives to support research and discovery by publishing the highest quality original scientific papers with a focus on basic, clinical and translational research. The journal’s subject areas cover a wide range of paediatric and adult rheumatological conditions from an international perspective. It is an official journal of the British Society for Rheumatology, published by Oxford University Press.
Rheumatology publishes original articles, reviews, editorials, guidelines, concise reports, meta-analyses, original case reports, clinical vignettes, letters and matters arising from published material. The journal takes pride in serving the global rheumatology community, with a focus on high societal impact in the form of podcasts, videos and extended social media presence, and utilizing metrics such as Altmetric. Keep up to date by following the journal on Twitter @RheumJnl.