中药逆转肺癌多药耐药及其机制研究进展

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Yuying Li, Fei Wang
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引用次数: 0

摘要

肺癌仍然是全球癌症相关死亡的主要原因,多药耐药(MDR)对其管理构成了重大障碍。中药以其全面的治疗策略和低不良反应发生率而闻名,因其减轻癌细胞耐多药耐药的能力而受到关注。然而,破解中药逆转肺癌耐多药耐药的确切机制是一项重大的科学挑战。本综述的目的是研究耐多药耐药在肺癌中的普遍表现,并强调在了解中药如何克服这种形式的耐药方面的最新进展。本文首先探讨中药的独特特性及其在逆转肺癌耐多药耐药方面的关键作用。随后,本文探讨了多种形式的耐多药耐药在肺癌中的作用,如细胞膜转运蛋白的异常表达、细胞内酶系统的失调、细胞凋亡的中断以及细胞修复机制的增强,强调了它们对肺癌治疗结果的不利影响。本综述的核心是对中药对抗耐多药的复杂机制进行全面分析,并评估其在肺癌治疗中的疗效。在此基础上,本文提出了利用中药克服耐多药耐药性的潜在未来研究方向。本综述旨在全面研究中药在逆转肺癌耐多药耐药方面的作用,并促进对其临床应用的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress on Traditional Chinese Medicines Reversing Multidrug Resistance and Mechanisms in Lung Cancer.

Lung cancer continues to be a primary contributor to cancer-related deaths globally, and multidrug resistance (MDR) poses a significant obstacle in its management. Traditional Chinese medicines (TCMs), recognized for their comprehensive therapeutic strategies and low incidence of adverse effects, have garnered attention due to their capacity to mitigate MDR in cancer cells. Nevertheless, deciphering the precise mechanisms through which TCMs reverse MDR in lung cancer presents a substantial scientific challenge. The objective of this review is to examine prevalent manifestations of MDR in lung cancer and underscore recent advancements in understanding how TCMs might surmount this form of resistance. The review begins by investigating the unique characteristics of TCMs and their pivotal function in reversing MDR in lung cancer. Subsequently, it explores various forms of MDR in lung cancer, such as aberrant expression of cell membrane transport proteins, dysregulation of intracellular enzyme systems, disrupted apoptosis, and heightened cellular repair mechanisms, emphasizing their detrimental impact on lung cancer treatment outcomes. Central to this review is a thorough analysis of the intricate mechanisms by which TCMs counteract MDR, along with an assessment of their efficacy in lung cancer therapy. Based on this analysis, the review offers insights into potential future research directions for utilizing TCMs to overcome MDR. This review seeks to provide a thorough examination of the role of TCMs in reversing MDR in lung cancer and to stimulate additional research into their clinical applications.

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来源期刊
CiteScore
7.80
自引率
2.90%
发文量
87
审稿时长
3 months
期刊介绍: Cancer Biotherapy and Radiopharmaceuticals is the established peer-reviewed journal, with over 25 years of cutting-edge content on innovative therapeutic investigations to ultimately improve cancer management. It is the only journal with the specific focus of cancer biotherapy and is inclusive of monoclonal antibodies, cytokine therapy, cancer gene therapy, cell-based therapies, and other forms of immunotherapies. The Journal includes extensive reporting on advancements in radioimmunotherapy, and the use of radiopharmaceuticals and radiolabeled peptides for the development of new cancer treatments.
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