{"title":"胎儿解剖在可活胎儿中的重要作用-羊膜畸形粘连，残缺复合体。","authors":"Harini Devi Jka, Nidhya Ganesan, Umamaheswari Gurusamy","doi":"10.1097/FM9.0000000000000230","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To identify the occurrence of the amniotic deformity adhesions, mutilation (ADAM) complex and imperative role of fetal autopsy in diagnosing this condition.</p><p><strong>Methods: </strong>A retrospective descriptive study spanning nine years, from January 2014 to January 2022, was conducted at the Department of Pathology within a tertiary care hospital in South India. The study focused on analyzing the clinical presentation, prenatal ultrasonogram, and morphological features of fetuses with the ADAM complex, limb body wall complex, or amniotic bands.</p><p><strong>Results: </strong>Among the 438 fetuses assessed during the study period, five fetuses showed features of the ADAM complex (0.01%). The most frequent gestational age observed was 12-18 weeks and most fetuses were female. The common anomaly encountered was limb defects, followed by abdominal and cranial anomalies.</p><p><strong>Conclusion: </strong>The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk anomalies. The pathologist plays a crucial role in understanding the complexities of the ADAM complex. Advanced antenatal imaging and therapies offer potential for prevention through improved counseling.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 3","pages":"134-140"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087891/pdf/","citationCount":"0","resultStr":"{\"title\":\"An Imperative Role of Fetal Autopsy in Previable Fetuses - Amniotic Deformity Adhesions, Mutilations Complex.\",\"authors\":\"Harini Devi Jka, Nidhya Ganesan, Umamaheswari Gurusamy\",\"doi\":\"10.1097/FM9.0000000000000230\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To identify the occurrence of the amniotic deformity adhesions, mutilation (ADAM) complex and imperative role of fetal autopsy in diagnosing this condition.</p><p><strong>Methods: </strong>A retrospective descriptive study spanning nine years, from January 2014 to January 2022, was conducted at the Department of Pathology within a tertiary care hospital in South India. The study focused on analyzing the clinical presentation, prenatal ultrasonogram, and morphological features of fetuses with the ADAM complex, limb body wall complex, or amniotic bands.</p><p><strong>Results: </strong>Among the 438 fetuses assessed during the study period, five fetuses showed features of the ADAM complex (0.01%). The most frequent gestational age observed was 12-18 weeks and most fetuses were female. The common anomaly encountered was limb defects, followed by abdominal and cranial anomalies.</p><p><strong>Conclusion: </strong>The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk anomalies. The pathologist plays a crucial role in understanding the complexities of the ADAM complex. Advanced antenatal imaging and therapies offer potential for prevention through improved counseling.</p>\",\"PeriodicalId\":74121,\"journal\":{\"name\":\"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)\",\"volume\":\"6 3\",\"pages\":\"134-140\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087891/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/FM9.0000000000000230\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/FM9.0000000000000230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
An Imperative Role of Fetal Autopsy in Previable Fetuses - Amniotic Deformity Adhesions, Mutilations Complex.
Objective: To identify the occurrence of the amniotic deformity adhesions, mutilation (ADAM) complex and imperative role of fetal autopsy in diagnosing this condition.
Methods: A retrospective descriptive study spanning nine years, from January 2014 to January 2022, was conducted at the Department of Pathology within a tertiary care hospital in South India. The study focused on analyzing the clinical presentation, prenatal ultrasonogram, and morphological features of fetuses with the ADAM complex, limb body wall complex, or amniotic bands.
Results: Among the 438 fetuses assessed during the study period, five fetuses showed features of the ADAM complex (0.01%). The most frequent gestational age observed was 12-18 weeks and most fetuses were female. The common anomaly encountered was limb defects, followed by abdominal and cranial anomalies.
Conclusion: The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk anomalies. The pathologist plays a crucial role in understanding the complexities of the ADAM complex. Advanced antenatal imaging and therapies offer potential for prevention through improved counseling.
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