Xiaoying He, Weibin Wu, Yan Wang, Jingyi Xiao, Juanjuan Feng, Hua Hong, Yue Chen, Rong Huang, Hongyu Guan, Hai Li
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The HF-present cohorts were matched to HF-absent controls using a 1:2 nearest-neighbor propensity score-matching (PSM) analysis. The matched cohorts were then compared across several endpoints, including mortality, length of stay (LOS), hospitalization costs, and postoperative complications.</p><p><strong>Results: </strong>After PSM, the study included 1781 patients who underwent lobectomy and 1157 who underwent sublobar resection, with 594 and 386 patients, respectively, having concurrent HF. In both the lobectomy and sublobar resection groups, patients with HF demonstrated significantly higher in-hospital mortality rates (<i>P</i> < .001), longer LOS (<i>P</i> < .001), increased total hospital charges (<i>P</i> < .001), and a greater risk for overall postoperative complications (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Among patients with lung cancer undergoing VATS, the presence of HF is associated with an increased risk of postoperative complications. This finding underscores the necessity for enhanced monitoring and care for patients with HF should be treated during the postoperative recovery phase.</p>","PeriodicalId":48591,"journal":{"name":"Clinical Medicine Insights-Oncology","volume":"19 ","pages":"11795549251319583"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095947/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Clinical Impact of Heart Failure on the Postoperative Outcomes for Lung Cancer Patients Undergoing Lobectomy and Sublobar Resection by Video-Assisted Thoracic Surgery: A Propensity Score-Matched Analysis of 2016-2020 HCUP-NIS Data.\",\"authors\":\"Xiaoying He, Weibin Wu, Yan Wang, Jingyi Xiao, Juanjuan Feng, Hua Hong, Yue Chen, Rong Huang, Hongyu Guan, Hai Li\",\"doi\":\"10.1177/11795549251319583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The clinical impact of heart failure (HF) on postoperative outcomes following video-assisted thoracic surgery (VATS) for lung cancer resection remains controversial. This study aimed to assess patient and hospital characteristics related to the type of surgery, as well as the independent impact of HF on surgical outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective analysis using data from the National Inpatient Sample database. A total of 20 693 patients aged 18 years or older, diagnosed with lung cancer, and undergoing lobectomy or sublobar resection via VATS between 2016 and 2020 were included. Patients were stratified based on the presence of HF. The HF-present cohorts were matched to HF-absent controls using a 1:2 nearest-neighbor propensity score-matching (PSM) analysis. The matched cohorts were then compared across several endpoints, including mortality, length of stay (LOS), hospitalization costs, and postoperative complications.</p><p><strong>Results: </strong>After PSM, the study included 1781 patients who underwent lobectomy and 1157 who underwent sublobar resection, with 594 and 386 patients, respectively, having concurrent HF. In both the lobectomy and sublobar resection groups, patients with HF demonstrated significantly higher in-hospital mortality rates (<i>P</i> < .001), longer LOS (<i>P</i> < .001), increased total hospital charges (<i>P</i> < .001), and a greater risk for overall postoperative complications (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Among patients with lung cancer undergoing VATS, the presence of HF is associated with an increased risk of postoperative complications. 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引用次数: 0
摘要
背景:心衰(HF)对肺癌电视胸外科手术(VATS)术后预后的临床影响仍有争议。本研究旨在评估与手术类型相关的患者和医院特征,以及心衰对手术结果的独立影响。方法:我们使用来自国家住院病人样本数据库的数据进行回顾性分析。在2016年至2020年期间,共有20693名年龄在18岁或以上,诊断为肺癌并通过VATS进行肺叶切除术或叶下切除术的患者被纳入研究。根据HF的存在对患者进行分层。使用1:2最近邻倾向评分匹配(PSM)分析,将存在hf的队列与不存在hf的对照组进行匹配。然后比较匹配队列的几个终点,包括死亡率、住院时间(LOS)、住院费用和术后并发症。结果:PSM后,该研究包括1781例肺叶切除术患者和1157例肺叶下切除术患者,分别有594例和386例并发心衰患者。在肺叶切除组和叶下切除组中,心衰患者的住院死亡率均显著升高(P P P P P)。结论:在接受VATS的肺癌患者中,心衰的存在与术后并发症的风险增加有关。这一发现强调了加强对心衰患者的监测和护理的必要性,心衰患者应该在术后恢复阶段进行治疗。
The Clinical Impact of Heart Failure on the Postoperative Outcomes for Lung Cancer Patients Undergoing Lobectomy and Sublobar Resection by Video-Assisted Thoracic Surgery: A Propensity Score-Matched Analysis of 2016-2020 HCUP-NIS Data.
Background: The clinical impact of heart failure (HF) on postoperative outcomes following video-assisted thoracic surgery (VATS) for lung cancer resection remains controversial. This study aimed to assess patient and hospital characteristics related to the type of surgery, as well as the independent impact of HF on surgical outcomes.
Methods: We conducted a retrospective analysis using data from the National Inpatient Sample database. A total of 20 693 patients aged 18 years or older, diagnosed with lung cancer, and undergoing lobectomy or sublobar resection via VATS between 2016 and 2020 were included. Patients were stratified based on the presence of HF. The HF-present cohorts were matched to HF-absent controls using a 1:2 nearest-neighbor propensity score-matching (PSM) analysis. The matched cohorts were then compared across several endpoints, including mortality, length of stay (LOS), hospitalization costs, and postoperative complications.
Results: After PSM, the study included 1781 patients who underwent lobectomy and 1157 who underwent sublobar resection, with 594 and 386 patients, respectively, having concurrent HF. In both the lobectomy and sublobar resection groups, patients with HF demonstrated significantly higher in-hospital mortality rates (P < .001), longer LOS (P < .001), increased total hospital charges (P < .001), and a greater risk for overall postoperative complications (P < .001).
Conclusions: Among patients with lung cancer undergoing VATS, the presence of HF is associated with an increased risk of postoperative complications. This finding underscores the necessity for enhanced monitoring and care for patients with HF should be treated during the postoperative recovery phase.
期刊介绍:
Clinical Medicine Insights: Oncology is an international, peer-reviewed, open access journal that focuses on all aspects of cancer research and treatment, in addition to related genetic, pathophysiological and epidemiological topics. Of particular but not exclusive importance are molecular biology, clinical interventions, controlled trials, therapeutics, pharmacology and drug delivery, and techniques of cancer surgery. The journal welcomes unsolicited article proposals.