全血治疗与平衡成分治疗与孤立性重型创伤性脑损伤患者生存的关系。

IF 2.1 Q3 CRITICAL CARE MEDICINE
Trauma Surgery & Acute Care Open Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.1136/tsaco-2023-001312
Shahin Mohseni, Maximilian Peter Forssten, Dhanisha Jayesh Trivedi, Andras Buki, Yang Cao, Ahmad Mohammad Ismail, Marcelo A F Ribeiro, Babak Sarani
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引用次数: 0

摘要

背景:全血输血(WBT)与损伤后失血性休克患者的止血改善和可能的死亡率有关,但尚未对孤立性重型创伤性脑损伤(TBI)患者进行研究。本研究的目的是比较平衡成分治疗(BCT)与WBT治疗孤立性严重TBI患者的结果。方法:在创伤质量改善计划(2016-2019)中登记的成人患者(≥18岁),患有钝性孤立性严重TBI(头部简易损伤评分≥3,其余身体部位≤1),并接受BCT(1-2:1包装红细胞(PRBC):新鲜冷冻血浆和1-2:1 PRBC:血小板)或WBT符合纳入条件。根据接受的输血,使用倾向评分匹配对患者进行匹配。研究的主要终点是住院死亡率。结果:217例患者接受了WBT (n=82)或BCT (n=135)。经倾向评分匹配后,对50对配对进行分析。与BCT组相比,WBT组的住院死亡率显著降低(43.1% vs 66.7%, p=0.025),相应的住院死亡率相对危险度(RR)降低35% (RR (CI 95%): 0.65(0.43 ~ 0.97))。然而,在比较手术治疗和保守治疗的亚组分析中,这种关联仅在接受神经外科干预的患者中保持显著。结论:与需要神经外科干预的BCT患者相比,严重孤立性TBI患者的WBT与更好的生存率相关。有必要采用适当的前瞻性研究设计对这一发现进行进一步调查。证据等级:III级,治疗性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between whole blood versus balanced component therapy and survival in isolated severe traumatic brain injury.

Background: Whole blood transfusion (WBT) is associated with improved hemostasis and possibly mortality in patients with hemorrhagic shock after injury but there are no studies in patients with isolated severe traumatic brain injury (TBI). The objective of this investigation was to compare outcomes of balanced component therapy (BCT) versus WBT in patients with an isolated severe TBI.

Methods: Adult patients (≥18 years) registered in the Trauma Quality Improvement Program (2016-2019) who suffered a blunt isolated severe TBI (head Abbreviated Injury Score ≥3 in the head and ≤1 in the remaining body regions) and who received a BCT (1-2:1 packed red blood cell (PRBC):fresh frozen plasma and 1-2:1 PRBC:platelets) or WBT were eligible for inclusion. Patients were matched, based on the transfusion received, using propensity score matching. The primary outcome of interest was in-hospital mortality.

Results: A total of 217 patients received either WBT (n=82) or BCT (n=135). After propensity score matching, 50 matched pairs were analyzed. The rate of in-hospital mortality was significantly lower in the WBT compared with BCT group (43.1% vs 66.7%, p=0.025) corresponding to a relative risk (RR) reduction of 35% in in-hospital mortality (RR (CI 95%): 0.65 (0.43 to 0.97)). However, in subgroup analyses comparing those who were managed surgically and conservatively, this association only remained significant among patients who underwent neurosurgical intervention.

Conclusions: WBT in patients with severe isolated TBI is associated with better survival compared with BCT in patients who require neurosurgical intervention. Further investigation into this finding using an appropriately powered, prospective study design is warranted.

Level of evidence: Level III, therapeutic.

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来源期刊
CiteScore
3.70
自引率
5.00%
发文量
71
审稿时长
12 weeks
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