胸部smarca4缺陷肿瘤的临床病理特征及治疗结果的回顾性分析

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI:10.1177/15330338251345377
Lijin Chen, Chunyang Su, Jiadi Yao, Xiaofeng Li, Xiaoyan Lin
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引用次数: 0

摘要

胸腔smarca4缺陷肿瘤是一种罕见的侵袭性恶性肿瘤,多发于肺或胸腔,对规范化治疗提出了挑战。这一挑战源于他们对化疗的耐药性和缺乏靶向治疗方案。方法回顾性分析胸椎smarca4缺陷肿瘤。本文概述了这些肿瘤的临床病理特征,并综述了晚期患者使用免疫检查点抑制剂(ICIs)联合化疗和单独化疗的临床结果。结果39例患者患有胸椎smarca4缺陷肿瘤,中位年龄为62岁。该队列由92.3%的男性组成,89.7%的人有吸烟史。在该组中,94.9%在诊断时为III/IV期疾病。smarca4缺陷的非小细胞肺癌(SMARCA4-DNSCLC)和smarca4缺陷的未分化肿瘤(SMARCA4-DUT)表现出不同的组织学和免疫组织化学特征。35例患者接受了全身治疗,ORR为51.4%,DCR为82.9%,中位OS为20.9个月。患者分为化疗组(28.6%)和ICIs +化疗组(71.4%)。ICIs +化疗组ORR为64.0%,DCR为96.0%,化疗组ORR分别为20.0%和50.0% (P < 0.05)
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Retrospective Insights into the Clinicopathological Features and Treatment Outcomes of Thoracic SMARCA4-Deficient Tumors.

Retrospective Insights into the Clinicopathological Features and Treatment Outcomes of Thoracic SMARCA4-Deficient Tumors.

Retrospective Insights into the Clinicopathological Features and Treatment Outcomes of Thoracic SMARCA4-Deficient Tumors.

Retrospective Insights into the Clinicopathological Features and Treatment Outcomes of Thoracic SMARCA4-Deficient Tumors.

IntroductionThoracic SMARCA4-deficient tumors, which are rare and aggressive malignancies found in the lung or thoracic cavity, present a challenge in treatment standardization. This challenge arises from their resistance to chemotherapy and the absence of targeted therapy options.MethodsThoracic SMARCA4-deficient tumors were identified retrospectively using pathology databases. The clinicopathological characteristics of these tumors are outlined, and the clinical outcomes of advanced patients treated with immune checkpoint inhibitors (ICIs) in combination with chemotherapy and chemotherapy alone are reviewed.ResultsThirty-nine patients had thoracic SMARCA4-deficient tumors, with a median age of 62 years. The cohort consisted of 92.3% males, and 89.7% had a history of smoking. Within this group, 94.9% had stage III/IV disease at diagnosis. SMARCA4-deficient non-small cell lung cancer (SMARCA4-DNSCLC) and SMARCA4-deficient undifferentiated tumors (SMARCA4-DUT) display distinct histological and immunohistochemical features. Thirty-five patients underwent systemic therapy, achieving an ORR of 51.4%, a DCR of 82.9%, and a median OS of 20.9 months. Patients were categorized into chemotherapy (28.6%) and ICIs plus chemotherapy (71.4%) groups. The ICIs plus chemotherapy group exhibited an ORR of 64.0% and a DCR of 96.0%, while the chemotherapy group had an ORR of 20.0% and 50.0%, respectively (P < .0001 for ORR and DCR). The median OS for ICIs plus chemotherapy and chemotherapy groups were 20.9 months and 6.5 months, and median PFS were 9.6 months and 3.5 months, respectively, all statistically significant (P < .05). Multivariate COX regression analysis indicated that treatment was an independent prognostic factor for OS.ConclusionThoracic SMARCA4-deficient tumors exhibit a lack of SMARCA4 expression, displaying high malignancy and aggressiveness while exhibiting poor response to standard chemotherapy. The combination of ICIs with chemotherapy could potentially serve as an effective treatment approach for thoracic SMARCA4-deficient tumors.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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