I型肌强直性营养不良(DM1) DMSXL小鼠模型逆转和消退学习改变:一项探索性研究

IF 3.2 4区 医学 Q2 CLINICAL NEUROLOGY
Sylvia Nieuwenhuis, Denys Kozakov, Kasia Kapusta, Geneviève Gourdon, Jeffrey C Glennon
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引用次数: 0

摘要

背景:1型肌强直性营养不良(DM1)患者的认知变化对生活质量有明显的负面影响。尽管如此,人们对这些变化的神经基础知之甚少。DM1患者表现出动机和认知灵活性的缺陷,反映出冷漠和强迫症/自闭症样特征。目的利用逆转学习和食欲消退任务可以很容易地评估这些特征。逆转学习评估规则变化后的学习能力,可以评估认知灵活性和习惯性反应,而食欲消退评估刺激-奖励关系从奖励到非奖励变化后抑制刺激-行动反应的能力。方法研究DM1、DMSXL小鼠模型在逆转学习和食欲消退任务中的表现。结果与C57/BL6野生型(WT)小鼠相似,DMSXL小鼠能够学习刺激奖励关系,但在反向学习实验的后期,DMSXL小鼠表现出增加的习惯样行为(正确反应数量增加)。在规则切换后,DMSXL小鼠产生的错误数量比WT增加,并且显示出提供正确反应的延迟时间增加。在消除任务中,DMSXL小鼠显示出比WT小鼠更快地消除先前奖励反应的能力。结论DMSXL和WT小鼠在认知灵活性、规则学习和动机方面存在差异,这可能有助于我们理解DM1的认知变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered reversal and extinction learning in the DMSXL mouse model of type I myotonic dystrophy (DM1): An exploratory study.

BackgroundCognitive changes in type 1 myotonic dystrophy (DM1) have a pronounced negative effect on quality of life measures. Despite this, the neural basis of these changes is poorly understood. DM1 patients demonstrate deficits in motivation and cognitive flexibility, reflective of apathy and obsessive-compulsive / autistic-like traits.ObjectiveThese traits can be readily assessed using reversal learning and appetitive extinction tasks. Reversal learning assesses the ability to learn following a change in a rule and can evaluate cognitive flexibility and habitual responding, while appetitive extinction assesses the ability to suppress a stimulus-action response following the change in the stimulus-reward relationship from rewarded to non-rewarded.MethodsIn this study we evaluated the performance of a mouse model of DM1, the DMSXL mouse in reversal learning and appetitive extinction tasks.ResultsSimilar to C57/BL6 wild type (WT) mice, DMSXL mice were able to learn stimulus reward relationships, however, in the late phase of reversal learning experiment DMSXL mice demonstrated increased habit-like behavior (increased number of correct responses). Following rule switching, DMSXL mice produced an increased number of errors compared to WT and showed increased latency to deliver correct responses. In the extinction task, DMSXL mice showed the ability to more rapidly extinguish a previously rewarded response than WT mice.ConclusionsThese findings constitute differences in cognitive flexibility, rule learning and motivation between DMSXL and WT mice which may inform our understanding of cognitive changes in DM1.

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来源期刊
Journal of neuromuscular diseases
Journal of neuromuscular diseases Medicine-Neurology (clinical)
CiteScore
5.10
自引率
6.10%
发文量
102
期刊介绍: The Journal of Neuromuscular Diseases aims to facilitate progress in understanding the molecular genetics/correlates, pathogenesis, pharmacology, diagnosis and treatment of acquired and genetic neuromuscular diseases (including muscular dystrophy, myasthenia gravis, spinal muscular atrophy, neuropathies, myopathies, myotonias and myositis). The journal publishes research reports, reviews, short communications, letters-to-the-editor, and will consider research that has negative findings. The journal is dedicated to providing an open forum for original research in basic science, translational and clinical research that will improve our fundamental understanding and lead to effective treatments of neuromuscular diseases.
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