粪便微生物群移植的应用现状及展望。

Juntendo medical journal Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.14789/ejmj.JMJ24-0045-R
Dai Ishikawa, Xiaochen Zhang, Akihito Nagahara
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引用次数: 0

摘要

近年来,肠道菌群对人体健康的影响越来越受到重视,强调了调节肠道菌群对患者护理的潜在益处。因此,粪便微生物群移植(FMT)已成为一种改善生态失调的新治疗方法。有必要对目前的研究和未来的发展可能性进行总结和讨论。这种先进的微生物疗法通过引入来自健康供体的多种微生物来恢复肠道微生物群,从而纠正生态失调并重建功能齐全的生态系统。在世界范围内,FMT的研究正在各个领域积极进行。本研究综述了FMT在胃肠道疾病、免疫检查点抑制剂、过敏性疾病、中枢神经系统疾病等方面的临床研究进展,以及我们正在进行的“FMT联合抗生素治疗溃疡性结肠炎”的临床研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Applications and Future Prospects of Fecal Microbiota Transplantation.

In recent years, the impact of gut microbiota on human health has gained increasing recognition, highlighting the potential benefits of regulating gut microbiota for patient care. Consequently, fecal microbiota transplantation (FMT) has emerged as a novel treatment for improving dysbiosis. It is necessary to summarize and discuss the current research and future development possibilities. This advanced microbial therapy restores the gut microbiome by introducing a diverse array of microorganisms from healthy donors, thereby correcting dysbiosis and re-establishing a fully functional ecosystem. Ongoing research on FMT is actively conducted in various fields worldwide. This study provides an overview of the progress of clinical research on the effects of FMT in gastrointestinal diseases, immune checkpoint inhibitors, allergic diseases, and central nervous system diseases, as well as the results of our ongoing clinical study on "FMT combined with antibiotics for ulcerative colitis."

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