图像引导放疗中基于深度学习的日千伏、兆伏和锥束CT图像自动分割结果比较。

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-05-21 DOI:10.1177/15330338251344198
Zhixing Wang, Chengyu Shi, Carson Wong, Seyi M Oderinde, William T Watkins, Kun Qing, Bo Liu, Terence M Williams, An Liu, Chunhui Han
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Quantitative metrics were calculated to compare auto-segmentation results with manual contours.ResultsThe auto-segmentation contours on kVCT images showed statistically significant difference in Dice similarity coefficient (DSC), Jaccard similarity coefficient, sensitivity index, inclusiveness index, and the 95<sup>th</sup> percentile Hausdorff distance, compared to those on kV-CBCT and MVCT images for most major organs. 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引用次数: 0

摘要

本研究旨在评估基于深度学习的自动分割模型在图像引导放射治疗中不同在线CT成像方式下的自动分割效果。方法首先对图像质量进行对照研究。回顾性检索了60例患者的扇束千伏CT (kVCT)、千伏锥束CT (kV- cbct)和兆伏CT (MVCT)的日常CT图像。对于每一种成像方式,一半的患者在骨盆区域接受CT扫描,而另一半在胸部区域接受CT扫描。使用卷积神经网络算法的深度学习自动分割模型生成危险器官轮廓。计算定量指标,将自动分割结果与人工轮廓进行比较。结果kVCT图像的自动分割轮廓在Dice相似系数(DSC)、Jaccard相似系数、敏感性指数、包容性指数和第95百分位Hausdorff距离上与kV-CBCT和MVCT图像相比,在大多数主要器官上具有统计学差异。在盆腔区域,肠容积的DSC差异最大,kVCT、kV-CBCT和MVCT的平均DSC分别为0.84±0.05、0.35±0.23和0.48±0.27 (p值p值
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparison of Deep Learning-Based Auto-Segmentation Results on Daily Kilovoltage, Megavoltage, and Cone Beam CT Images in Image-Guided Radiotherapy.

Comparison of Deep Learning-Based Auto-Segmentation Results on Daily Kilovoltage, Megavoltage, and Cone Beam CT Images in Image-Guided Radiotherapy.

Comparison of Deep Learning-Based Auto-Segmentation Results on Daily Kilovoltage, Megavoltage, and Cone Beam CT Images in Image-Guided Radiotherapy.

Comparison of Deep Learning-Based Auto-Segmentation Results on Daily Kilovoltage, Megavoltage, and Cone Beam CT Images in Image-Guided Radiotherapy.

IntroductionThis study aims to evaluate auto-segmentation results using deep learning-based auto-segmentation models on different online CT imaging modalities in image-guided radiotherapy.MethodsPhantom studies were first performed to benchmark image quality. Daily CT images for sixty patients were retrospectively retrieved from fan-beam kilovoltage CT (kVCT), kV cone-beam CT (kV-CBCT), and megavoltage CT (MVCT) scans. For each imaging modality, half of the patients received CT scans in the pelvic region, while the other half in the thoracic region. Deep learning auto-segmentation models using a convolutional neural network algorithm were used to generate organs-at-risk contours. Quantitative metrics were calculated to compare auto-segmentation results with manual contours.ResultsThe auto-segmentation contours on kVCT images showed statistically significant difference in Dice similarity coefficient (DSC), Jaccard similarity coefficient, sensitivity index, inclusiveness index, and the 95th percentile Hausdorff distance, compared to those on kV-CBCT and MVCT images for most major organs. In the pelvic region, the largest difference in DSC was observed for the bowel volume with an average DSC of 0.84 ± 0.05, 0.35 ± 0.23, and 0.48 ± 0.27 for kVCT, kV-CBCT, and MVCT images, respectively (p-value < 0.05); in the thoracic region, the largest difference in DSC was found for the esophagus with an average DSC of 0.63 ± 0.16, 0.18 ± 0.13, and 0.22 ± 0.08 for kVCT, kV-CBCT, and MVCT images, respectively (p-value < 0.05).ConclusionDeep learning-based auto-segmentation models showed better agreement with manual contouring when using kVCT images compared to kV-CBCT or MVCT images. However, manual correction remains necessary after auto-segmentation with all imaging modalities, particularly for organs with limited contrast from surrounding tissues. These findings underscore the potential and limits in applying deep learning-based auto-segmentation models for adaptive radiotherapy.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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