{"title":"OLE RNA作为天然完整膜RNA的意义。","authors":"Seth Eugene Lyon, Ronald R Breaker","doi":"10.1261/rna.080489.125","DOIUrl":null,"url":null,"abstract":"<p><p>Ornate, large, extremophilic (OLE) RNAs, found in many Gram-positive bacterial species, represent an unusual class of noncoding RNAs which form a large ribonucleoprotein complex that localizes to cell membranes. Although the precise biochemical functions of OLE RNAs remain to be discovered, several lines of evidence suggest that they participate in forming particles that function as the master regulators of their bacterial hosts. Thus, OLE RNA might be a molecular relic of RNA World organisms that contributed to cellular stress responses long before the evolutionary emergence of proteins. Recent reports of partial 3-D structures strongly suggest that OLE RNAs form a molecular dimer whose complex structure spans the phospholipid bilayer of membranes. The implications of these findings on the functions of OLE RNA and on the capabilities of RNA polymers more broadly are discussed.</p>","PeriodicalId":21401,"journal":{"name":"RNA","volume":" ","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Implications for OLE RNA as a natural integral membrane RNA.\",\"authors\":\"Seth Eugene Lyon, Ronald R Breaker\",\"doi\":\"10.1261/rna.080489.125\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ornate, large, extremophilic (OLE) RNAs, found in many Gram-positive bacterial species, represent an unusual class of noncoding RNAs which form a large ribonucleoprotein complex that localizes to cell membranes. Although the precise biochemical functions of OLE RNAs remain to be discovered, several lines of evidence suggest that they participate in forming particles that function as the master regulators of their bacterial hosts. Thus, OLE RNA might be a molecular relic of RNA World organisms that contributed to cellular stress responses long before the evolutionary emergence of proteins. Recent reports of partial 3-D structures strongly suggest that OLE RNAs form a molecular dimer whose complex structure spans the phospholipid bilayer of membranes. The implications of these findings on the functions of OLE RNA and on the capabilities of RNA polymers more broadly are discussed.</p>\",\"PeriodicalId\":21401,\"journal\":{\"name\":\"RNA\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RNA\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1261/rna.080489.125\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RNA","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1261/rna.080489.125","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Implications for OLE RNA as a natural integral membrane RNA.
Ornate, large, extremophilic (OLE) RNAs, found in many Gram-positive bacterial species, represent an unusual class of noncoding RNAs which form a large ribonucleoprotein complex that localizes to cell membranes. Although the precise biochemical functions of OLE RNAs remain to be discovered, several lines of evidence suggest that they participate in forming particles that function as the master regulators of their bacterial hosts. Thus, OLE RNA might be a molecular relic of RNA World organisms that contributed to cellular stress responses long before the evolutionary emergence of proteins. Recent reports of partial 3-D structures strongly suggest that OLE RNAs form a molecular dimer whose complex structure spans the phospholipid bilayer of membranes. The implications of these findings on the functions of OLE RNA and on the capabilities of RNA polymers more broadly are discussed.
期刊介绍:
RNA is a monthly journal which provides rapid publication of significant original research in all areas of RNA structure and function in eukaryotic, prokaryotic, and viral systems. It covers a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; alternative processing: cis-acting elements and trans-acting factors; ribosome structure and function; translational control; RNA catalysis; tRNA structure, function, biogenesis and identity; RNA editing; rRNA structure, function and biogenesis; RNA transport and localization; regulatory RNAs; large and small RNP structure, function and biogenesis; viral RNA metabolism; RNA stability and turnover; in vitro evolution; and RNA chemistry.