OLE RNA作为天然完整膜RNA的意义。

IF 4.2 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
RNA Pub Date : 2025-05-20 DOI:10.1261/rna.080489.125
Seth Eugene Lyon, Ronald R Breaker
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引用次数: 0

摘要

在许多革兰氏阳性细菌物种中发现的华丽的,大的,嗜极性(OLE) rna代表了一类不寻常的非编码rna,它们形成一个大的核糖核蛋白复合物,定位于细胞膜。尽管OLE rna的精确生化功能仍有待发现,但一些证据表明,它们参与形成颗粒,作为细菌宿主的主要调节剂。因此,OLE RNA可能是早在蛋白质进化出现之前就参与细胞应激反应的RNA世界生物的分子遗迹。最近对部分三维结构的报道强烈表明,OLE rna形成一种分子二聚体,其复杂结构跨越磷脂双分子膜。这些发现对OLE RNA的功能和更广泛的RNA聚合物的能力的影响进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Implications for OLE RNA as a natural integral membrane RNA.

Ornate, large, extremophilic (OLE) RNAs, found in many Gram-positive bacterial species, represent an unusual class of noncoding RNAs which form a large ribonucleoprotein complex that localizes to cell membranes. Although the precise biochemical functions of OLE RNAs remain to be discovered, several lines of evidence suggest that they participate in forming particles that function as the master regulators of their bacterial hosts. Thus, OLE RNA might be a molecular relic of RNA World organisms that contributed to cellular stress responses long before the evolutionary emergence of proteins. Recent reports of partial 3-D structures strongly suggest that OLE RNAs form a molecular dimer whose complex structure spans the phospholipid bilayer of membranes. The implications of these findings on the functions of OLE RNA and on the capabilities of RNA polymers more broadly are discussed.

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来源期刊
RNA
RNA 生物-生化与分子生物学
CiteScore
8.30
自引率
2.20%
发文量
101
审稿时长
2.6 months
期刊介绍: RNA is a monthly journal which provides rapid publication of significant original research in all areas of RNA structure and function in eukaryotic, prokaryotic, and viral systems. It covers a broad range of subjects in RNA research, including: structural analysis by biochemical or biophysical means; mRNA structure, function and biogenesis; alternative processing: cis-acting elements and trans-acting factors; ribosome structure and function; translational control; RNA catalysis; tRNA structure, function, biogenesis and identity; RNA editing; rRNA structure, function and biogenesis; RNA transport and localization; regulatory RNAs; large and small RNP structure, function and biogenesis; viral RNA metabolism; RNA stability and turnover; in vitro evolution; and RNA chemistry.
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