{"title":"单细胞转录揭示胚胎肾脏发育的关键转录因子。","authors":"Jingxian Huang, Bing Yan, Hongwei Wu, Hougang Yang, Shaodong Luan, Haiyan Yu, Wei Shi, Pingping Ye, Fang Yuan, Qiang Yan, Fanna Liu, Lianghong Yin, Donge Tang, Yong Dai","doi":"10.1007/s11010-025-05307-x","DOIUrl":null,"url":null,"abstract":"<p><p>The development of the kidney is a complex process involving the differentiation of renal progenitor cells into various specialized cell types, including renal tubular epithelial cells and podocytes. Understanding the molecular mechanisms that govern this differentiation process is crucial for unraveling the intricacies of kidney development. Recent advances in single-cell RNA sequencing technology have enabled researchers to explore the heterogeneity of renal progenitor cells at an unprecedented resolution, offering new insights into the distinct subpopulations and transcriptional landscapes within these cells. Our analysis revealed the presence of distinct subpopulations within renal progenitor cells. Furthermore, we identified key transcription factors that are crucial for the differentiation of these progenitors into renal tubular epithelial cells and podocytes. These findings provide new insights into the molecular mechanisms of kidney development, highlighting the role of specific transcription factors in the differentiation of renal progenitor cells. Although further research is needed to fully validate these findings and their therapeutic potential, this study provides a valuable foundation for future exploration of kidney regeneration strategies.</p>","PeriodicalId":18724,"journal":{"name":"Molecular and Cellular Biochemistry","volume":" ","pages":"5075-5089"},"PeriodicalIF":3.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476426/pdf/","citationCount":"0","resultStr":"{\"title\":\"Single cell transcription revealing key transcription factors in embryonic kidney development.\",\"authors\":\"Jingxian Huang, Bing Yan, Hongwei Wu, Hougang Yang, Shaodong Luan, Haiyan Yu, Wei Shi, Pingping Ye, Fang Yuan, Qiang Yan, Fanna Liu, Lianghong Yin, Donge Tang, Yong Dai\",\"doi\":\"10.1007/s11010-025-05307-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The development of the kidney is a complex process involving the differentiation of renal progenitor cells into various specialized cell types, including renal tubular epithelial cells and podocytes. Understanding the molecular mechanisms that govern this differentiation process is crucial for unraveling the intricacies of kidney development. Recent advances in single-cell RNA sequencing technology have enabled researchers to explore the heterogeneity of renal progenitor cells at an unprecedented resolution, offering new insights into the distinct subpopulations and transcriptional landscapes within these cells. Our analysis revealed the presence of distinct subpopulations within renal progenitor cells. Furthermore, we identified key transcription factors that are crucial for the differentiation of these progenitors into renal tubular epithelial cells and podocytes. These findings provide new insights into the molecular mechanisms of kidney development, highlighting the role of specific transcription factors in the differentiation of renal progenitor cells. Although further research is needed to fully validate these findings and their therapeutic potential, this study provides a valuable foundation for future exploration of kidney regeneration strategies.</p>\",\"PeriodicalId\":18724,\"journal\":{\"name\":\"Molecular and Cellular Biochemistry\",\"volume\":\" \",\"pages\":\"5075-5089\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476426/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and Cellular Biochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11010-025-05307-x\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Biochemistry","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11010-025-05307-x","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Single cell transcription revealing key transcription factors in embryonic kidney development.
The development of the kidney is a complex process involving the differentiation of renal progenitor cells into various specialized cell types, including renal tubular epithelial cells and podocytes. Understanding the molecular mechanisms that govern this differentiation process is crucial for unraveling the intricacies of kidney development. Recent advances in single-cell RNA sequencing technology have enabled researchers to explore the heterogeneity of renal progenitor cells at an unprecedented resolution, offering new insights into the distinct subpopulations and transcriptional landscapes within these cells. Our analysis revealed the presence of distinct subpopulations within renal progenitor cells. Furthermore, we identified key transcription factors that are crucial for the differentiation of these progenitors into renal tubular epithelial cells and podocytes. These findings provide new insights into the molecular mechanisms of kidney development, highlighting the role of specific transcription factors in the differentiation of renal progenitor cells. Although further research is needed to fully validate these findings and their therapeutic potential, this study provides a valuable foundation for future exploration of kidney regeneration strategies.
期刊介绍:
Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell.
In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.