日本法定成年年龄降低后，年轻相关献血者捐献造血干细胞的安全性。

IF 1.8 4区医学 Q3 HEMATOLOGY

International Journal of Hematology Pub Date : 2025-10-01 Epub Date: 2025-05-20 DOI:10.1007/s12185-025-04007-y

Tsuneaki Hirakawa, Hiromasa Yabe, Masayuki Hino, Noriko Doki, Satoshi Yoshihara, Shuichi Ota, Takahiro Fukuda, Hirohisa Nakamae, Jun Ishikawa, Yuta Hasegawa, Tetsuya Nishida, Noboru Asada, Hidekazu Nishikii, Toshiro Kawakita, Masayoshi Masuko, Yasuo Mori, Toshihiko Ando, Kazuhiko Ikeda, Marie Ohbiki, Yoshiko Atsuta, Nobuhiro Tsukada, Ryu Yanagisawa

{"title":"日本法定成年年龄降低后，年轻相关献血者捐献造血干细胞的安全性。","authors":"Tsuneaki Hirakawa, Hiromasa Yabe, Masayuki Hino, Noriko Doki, Satoshi Yoshihara, Shuichi Ota, Takahiro Fukuda, Hirohisa Nakamae, Jun Ishikawa, Yuta Hasegawa, Tetsuya Nishida, Noboru Asada, Hidekazu Nishikii, Toshiro Kawakita, Masayoshi Masuko, Yasuo Mori, Toshihiko Ando, Kazuhiko Ikeda, Marie Ohbiki, Yoshiko Atsuta, Nobuhiro Tsukada, Ryu Yanagisawa","doi":"10.1007/s12185-025-04007-y","DOIUrl":null,"url":null,"abstract":"The Japanese government's recent lowering of the legal adult age to 18 may prompt reconsideration of the minimum age for donors in the Japan Marrow Donor Program. To provide foundational data for decision-makers, this retrospective study analyzed the safety of hematopoietic stem cell donation among 1999 related donors aged 18 to 24 years, using data from the Japanese Data Center for Hematopoietic Cell Transplantation. Severe adverse events (SAEs) occurred in 1.0% of all donors, with no significant difference between those aged 18 to 19 (0.7%) and those aged 20 to 24 (1.1%) (P = 0.59). Risk factors for SAEs included ongoing asthma treatment (HR 34.6, 95% CI 2.29-524.00, P < 0.01), history of asthma (HR 11.3, 95% CI 2.46-51.70, P < 0.01), and female sex (HR 4.64, 95% CI 1.51-14.20, P < 0.01). However, age of 18 to 19 was not a significant risk factor (HR 0.53, 95% CI 0.14-2.01, P = 0.35). These results indicate that stem cell donation safety in 18- to 19-year-old donors is comparable to that in 20- to 24-year-olds, with increased risks linked to asthma and female sex.","PeriodicalId":13992,"journal":{"name":"International Journal of Hematology","volume":" ","pages":"572-582"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Safety of hematopoietic stem cell donation from young related donors following the lowering of the age of legal adulthood in Japan.\",\"authors\":\"Tsuneaki Hirakawa, Hiromasa Yabe, Masayuki Hino, Noriko Doki, Satoshi Yoshihara, Shuichi Ota, Takahiro Fukuda, Hirohisa Nakamae, Jun Ishikawa, Yuta Hasegawa, Tetsuya Nishida, Noboru Asada, Hidekazu Nishikii, Toshiro Kawakita, Masayoshi Masuko, Yasuo Mori, Toshihiko Ando, Kazuhiko Ikeda, Marie Ohbiki, Yoshiko Atsuta, Nobuhiro Tsukada, Ryu Yanagisawa\",\"doi\":\"10.1007/s12185-025-04007-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Japanese government's recent lowering of the legal adult age to 18 may prompt reconsideration of the minimum age for donors in the Japan Marrow Donor Program. To provide foundational data for decision-makers, this retrospective study analyzed the safety of hematopoietic stem cell donation among 1999 related donors aged 18 to 24 years, using data from the Japanese Data Center for Hematopoietic Cell Transplantation. Severe adverse events (SAEs) occurred in 1.0% of all donors, with no significant difference between those aged 18 to 19 (0.7%) and those aged 20 to 24 (1.1%) (P = 0.59). Risk factors for SAEs included ongoing asthma treatment (HR 34.6, 95% CI 2.29-524.00, P < 0.01), history of asthma (HR 11.3, 95% CI 2.46-51.70, P < 0.01), and female sex (HR 4.64, 95% CI 1.51-14.20, P < 0.01). However, age of 18 to 19 was not a significant risk factor (HR 0.53, 95% CI 0.14-2.01, P = 0.35). These results indicate that stem cell donation safety in 18- to 19-year-old donors is comparable to that in 20- to 24-year-olds, with increased risks linked to asthma and female sex.\",\"PeriodicalId\":13992,\"journal\":{\"name\":\"International Journal of Hematology\",\"volume\":\" \",\"pages\":\"572-582\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12185-025-04007-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12185-025-04007-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

日本政府最近将法定成年年龄降至18岁，这可能会促使人们重新考虑日本骨髓捐赠计划中捐献骨髓的最低年龄。为了给决策者提供基础数据，本回顾性研究使用日本造血细胞移植数据中心的数据，分析了1999年18 - 24岁相关供者的造血干细胞捐赠安全性。严重不良事件（SAEs）发生率为1.0%，18 ~ 19岁（0.7%）和20 ~ 24岁（1.1%）之间无显著差异（P = 0.59）。急性呼吸道感染的危险因素包括持续的哮喘治疗(HR 34.6, 95% CI 2.29-524.00， P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Safety of hematopoietic stem cell donation from young related donors following the lowering of the age of legal adulthood in Japan.

The Japanese government's recent lowering of the legal adult age to 18 may prompt reconsideration of the minimum age for donors in the Japan Marrow Donor Program. To provide foundational data for decision-makers, this retrospective study analyzed the safety of hematopoietic stem cell donation among 1999 related donors aged 18 to 24 years, using data from the Japanese Data Center for Hematopoietic Cell Transplantation. Severe adverse events (SAEs) occurred in 1.0% of all donors, with no significant difference between those aged 18 to 19 (0.7%) and those aged 20 to 24 (1.1%) (P = 0.59). Risk factors for SAEs included ongoing asthma treatment (HR 34.6, 95% CI 2.29-524.00, P < 0.01), history of asthma (HR 11.3, 95% CI 2.46-51.70, P < 0.01), and female sex (HR 4.64, 95% CI 1.51-14.20, P < 0.01). However, age of 18 to 19 was not a significant risk factor (HR 0.53, 95% CI 0.14-2.01, P = 0.35). These results indicate that stem cell donation safety in 18- to 19-year-old donors is comparable to that in 20- to 24-year-olds, with increased risks linked to asthma and female sex.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Hematology 医学-血液学

CiteScore

3.90

自引率

4.80%

发文量

223

审稿时长

6 months

期刊介绍： The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.