{"title":"基于比例人口输入函数的胰腺癌简化Patlak参数成像的可行性。","authors":"Zhixin Hao, Haiqiong Zhang, Yonghong Dang, Jiangdong Qiu, Mengshi Yan, Xinchun Yan, Zhenghai Huang, Chao Ren, Taiping Zhang, Wenming Wu, Li Huo","doi":"10.1186/s40658-025-00758-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study evaluates the feasibility of using a simplified Patlak parametric imaging technique with a scaled population-based input function (sPBIF) in pancreatic cancer.</p><p><strong>Methods: </strong>Twenty-six patients underwent multi-bed, multi-pass [<sup>18</sup>F]FDG PET/CT scans, from which both dynamic and static PET images were reconstructed. Patlak parametric images were generated from the dynamic PET series using both the image-derived input function (IDIF) and the sPBIF. The consistency between IDIF and sPBIF was evaluated by comparing the area under the curve (AUC) and Patlak parameters derived from both input functions. The detectability of pancreatic lesions, assessed by tumor-to-background ratio (TBR) and contrast-to-noise ratio (CNR), was compared between SUV and Patlak parametric images. Additionally, the correlation between clinicopathological features and PET parameters, including SUV and Patlak values, was analyzed.</p><p><strong>Results: </strong>We found good agreement between the AUC for IDIF and sPBIF with correlation coefficients of 0.87 and 0.93 for the 0-30 min and 0-50 min intervals, respectively. The Patlak parameters from IDIF and sPBIF presented correlation coefficients higher than 0.94. The SUV and Patlak K<sub>i</sub> exhibited correlation coefficients greater than 0.92 and 0.73 in malignant and benign pancreatic lesions, respectively. The SUV and Patlak V<sub>0</sub> correlated with correlation coefficients higher than 0.75 in benign lesions, but exhibited only a weak correlation in malignant lesions. The TBR of Patlak K<sub>i</sub> was significantly higher in malignant lesions compared to SUV. However, the CNR of Patlak K<sub>i</sub> was lower due to increased noise in the parametric images. Most clinicopathological features showed weak correlation with PET parameters, except for a marginal classification of lesion differentiation by the maximum K<sub>i</sub> value.</p><p><strong>Conclusions: </strong>The sPBIF approach enables the acquisition of additional Patlak parametric images alongside static SUV imaging in pancreatic cancer patients. K<sub>i</sub> parametric imaging provided higher contrast than static imaging for detecting pancreatic lesions.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"46"},"PeriodicalIF":3.0000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092890/pdf/","citationCount":"0","resultStr":"{\"title\":\"Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer.\",\"authors\":\"Zhixin Hao, Haiqiong Zhang, Yonghong Dang, Jiangdong Qiu, Mengshi Yan, Xinchun Yan, Zhenghai Huang, Chao Ren, Taiping Zhang, Wenming Wu, Li Huo\",\"doi\":\"10.1186/s40658-025-00758-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study evaluates the feasibility of using a simplified Patlak parametric imaging technique with a scaled population-based input function (sPBIF) in pancreatic cancer.</p><p><strong>Methods: </strong>Twenty-six patients underwent multi-bed, multi-pass [<sup>18</sup>F]FDG PET/CT scans, from which both dynamic and static PET images were reconstructed. Patlak parametric images were generated from the dynamic PET series using both the image-derived input function (IDIF) and the sPBIF. The consistency between IDIF and sPBIF was evaluated by comparing the area under the curve (AUC) and Patlak parameters derived from both input functions. The detectability of pancreatic lesions, assessed by tumor-to-background ratio (TBR) and contrast-to-noise ratio (CNR), was compared between SUV and Patlak parametric images. Additionally, the correlation between clinicopathological features and PET parameters, including SUV and Patlak values, was analyzed.</p><p><strong>Results: </strong>We found good agreement between the AUC for IDIF and sPBIF with correlation coefficients of 0.87 and 0.93 for the 0-30 min and 0-50 min intervals, respectively. The Patlak parameters from IDIF and sPBIF presented correlation coefficients higher than 0.94. The SUV and Patlak K<sub>i</sub> exhibited correlation coefficients greater than 0.92 and 0.73 in malignant and benign pancreatic lesions, respectively. The SUV and Patlak V<sub>0</sub> correlated with correlation coefficients higher than 0.75 in benign lesions, but exhibited only a weak correlation in malignant lesions. The TBR of Patlak K<sub>i</sub> was significantly higher in malignant lesions compared to SUV. However, the CNR of Patlak K<sub>i</sub> was lower due to increased noise in the parametric images. Most clinicopathological features showed weak correlation with PET parameters, except for a marginal classification of lesion differentiation by the maximum K<sub>i</sub> value.</p><p><strong>Conclusions: </strong>The sPBIF approach enables the acquisition of additional Patlak parametric images alongside static SUV imaging in pancreatic cancer patients. K<sub>i</sub> parametric imaging provided higher contrast than static imaging for detecting pancreatic lesions.</p>\",\"PeriodicalId\":11559,\"journal\":{\"name\":\"EJNMMI Physics\",\"volume\":\"12 1\",\"pages\":\"46\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092890/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40658-025-00758-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40658-025-00758-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer.
Background: This study evaluates the feasibility of using a simplified Patlak parametric imaging technique with a scaled population-based input function (sPBIF) in pancreatic cancer.
Methods: Twenty-six patients underwent multi-bed, multi-pass [18F]FDG PET/CT scans, from which both dynamic and static PET images were reconstructed. Patlak parametric images were generated from the dynamic PET series using both the image-derived input function (IDIF) and the sPBIF. The consistency between IDIF and sPBIF was evaluated by comparing the area under the curve (AUC) and Patlak parameters derived from both input functions. The detectability of pancreatic lesions, assessed by tumor-to-background ratio (TBR) and contrast-to-noise ratio (CNR), was compared between SUV and Patlak parametric images. Additionally, the correlation between clinicopathological features and PET parameters, including SUV and Patlak values, was analyzed.
Results: We found good agreement between the AUC for IDIF and sPBIF with correlation coefficients of 0.87 and 0.93 for the 0-30 min and 0-50 min intervals, respectively. The Patlak parameters from IDIF and sPBIF presented correlation coefficients higher than 0.94. The SUV and Patlak Ki exhibited correlation coefficients greater than 0.92 and 0.73 in malignant and benign pancreatic lesions, respectively. The SUV and Patlak V0 correlated with correlation coefficients higher than 0.75 in benign lesions, but exhibited only a weak correlation in malignant lesions. The TBR of Patlak Ki was significantly higher in malignant lesions compared to SUV. However, the CNR of Patlak Ki was lower due to increased noise in the parametric images. Most clinicopathological features showed weak correlation with PET parameters, except for a marginal classification of lesion differentiation by the maximum Ki value.
Conclusions: The sPBIF approach enables the acquisition of additional Patlak parametric images alongside static SUV imaging in pancreatic cancer patients. Ki parametric imaging provided higher contrast than static imaging for detecting pancreatic lesions.
期刊介绍：
EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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