利培酮作为双相情感障碍患者强迫症症状的辅助治疗:一项随机、双盲、安慰剂对照的临床试验

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Ali Sahraian, Mahsa Ghavipisheh, Leila Razeghian Jahromi, Iman Ahrari, Arash Mowla
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引用次数: 0

摘要

治疗双相情感障碍(BD)患者的强迫症(OCD)症状具有挑战性。本研究探讨利培酮对双相障碍患者强迫症症状的治疗效果。在一项盲法随机安慰剂对照试验中,42名同时患有BD和OCD症状的患者被随机分配接受利培酮或安慰剂治疗。两组患者均处于双相障碍的愉悦期。在研究开始前和研究开始后第4、8、12周,采用耶鲁-布朗强迫行为量表(YBOCS)对两组患者的强迫症症状进行测量。所有患者都完成了试验,无一人退出。在最初的评估中,利培酮组和安慰剂组的YBOCS评分没有显著差异。治疗12周后,利培酮组强迫症症状明显低于安慰剂组[YBOCS: 5(3)比11(6.5),p值< 0.001]。利培酮组YBOCS下降超过35%的患者数量明显高于安慰剂组[20/21(95.23%)比10/21 (47.61%),p值= 0.001]。利培酮能有效减轻BD患者的强迫症症状。这种治疗是安全且耐受性良好的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risperidone as an adjuvant treatment for obsessive-compulsive symptoms in patients with bipolar disorder: a randomized, double-blind, placebo-controlled clinical trial.

Treatment of obsessive-compulsive disorder (OCD) symptoms in patients with bipolar disorder (BD) is challenging. In this research, the therapeutic effects of risperidone on OCD symptoms in patients with BD are investigated. Forty-two patients with concurrent BD and OCD symptoms were randomly assigned to receive risperidone or a placebo in a blinded randomized placebo-controlled trial. The patients of both groups were in the euthymic phase of BD. OCD symptoms were measured by the Yale-Brown Obsessive Compulsive Behavior Scale (YBOCS) before the study initiation and at the 4th,8th, and 12th weeks in each group. All the patients completed the trial with no dropouts. At the initial evaluation, the risperidone and placebo groups did not differ significantly regarding their YBOCS scores. After 12 weeks of treatment, the OCD symptoms were significantly lower in the risperidone group compared to the placebo group [YBOCS: 5(3) vs. 11(6.5), P-value < 0.001]. The number of patients with more than 35% reduction in YBOCS was significantly higher in the risperidone group compared to the placebo group [20/21 (95.23%) vs. 10/21 (47.61%), P-value = 0.001]. Risperidone could effectively reduce OCD symptoms in BD patients. The treatment was safe and well tolerated.

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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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