Ali Sahraian, Mahsa Ghavipisheh, Leila Razeghian Jahromi, Iman Ahrari, Arash Mowla
{"title":"利培酮作为双相情感障碍患者强迫症症状的辅助治疗:一项随机、双盲、安慰剂对照的临床试验","authors":"Ali Sahraian, Mahsa Ghavipisheh, Leila Razeghian Jahromi, Iman Ahrari, Arash Mowla","doi":"10.1097/YIC.0000000000000592","DOIUrl":null,"url":null,"abstract":"<p><p>Treatment of obsessive-compulsive disorder (OCD) symptoms in patients with bipolar disorder (BD) is challenging. In this research, the therapeutic effects of risperidone on OCD symptoms in patients with BD are investigated. Forty-two patients with concurrent BD and OCD symptoms were randomly assigned to receive risperidone or a placebo in a blinded randomized placebo-controlled trial. The patients of both groups were in the euthymic phase of BD. OCD symptoms were measured by the Yale-Brown Obsessive Compulsive Behavior Scale (YBOCS) before the study initiation and at the 4th,8th, and 12th weeks in each group. All the patients completed the trial with no dropouts. At the initial evaluation, the risperidone and placebo groups did not differ significantly regarding their YBOCS scores. After 12 weeks of treatment, the OCD symptoms were significantly lower in the risperidone group compared to the placebo group [YBOCS: 5(3) vs. 11(6.5), P-value < 0.001]. The number of patients with more than 35% reduction in YBOCS was significantly higher in the risperidone group compared to the placebo group [20/21 (95.23%) vs. 10/21 (47.61%), P-value = 0.001]. Risperidone could effectively reduce OCD symptoms in BD patients. The treatment was safe and well tolerated.</p>","PeriodicalId":13698,"journal":{"name":"International Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risperidone as an adjuvant treatment for obsessive-compulsive symptoms in patients with bipolar disorder: a randomized, double-blind, placebo-controlled clinical trial.\",\"authors\":\"Ali Sahraian, Mahsa Ghavipisheh, Leila Razeghian Jahromi, Iman Ahrari, Arash Mowla\",\"doi\":\"10.1097/YIC.0000000000000592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Treatment of obsessive-compulsive disorder (OCD) symptoms in patients with bipolar disorder (BD) is challenging. In this research, the therapeutic effects of risperidone on OCD symptoms in patients with BD are investigated. Forty-two patients with concurrent BD and OCD symptoms were randomly assigned to receive risperidone or a placebo in a blinded randomized placebo-controlled trial. The patients of both groups were in the euthymic phase of BD. OCD symptoms were measured by the Yale-Brown Obsessive Compulsive Behavior Scale (YBOCS) before the study initiation and at the 4th,8th, and 12th weeks in each group. All the patients completed the trial with no dropouts. At the initial evaluation, the risperidone and placebo groups did not differ significantly regarding their YBOCS scores. After 12 weeks of treatment, the OCD symptoms were significantly lower in the risperidone group compared to the placebo group [YBOCS: 5(3) vs. 11(6.5), P-value < 0.001]. The number of patients with more than 35% reduction in YBOCS was significantly higher in the risperidone group compared to the placebo group [20/21 (95.23%) vs. 10/21 (47.61%), P-value = 0.001]. Risperidone could effectively reduce OCD symptoms in BD patients. The treatment was safe and well tolerated.</p>\",\"PeriodicalId\":13698,\"journal\":{\"name\":\"International Clinical Psychopharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Clinical Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/YIC.0000000000000592\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Clinical Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/YIC.0000000000000592","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Risperidone as an adjuvant treatment for obsessive-compulsive symptoms in patients with bipolar disorder: a randomized, double-blind, placebo-controlled clinical trial.
Treatment of obsessive-compulsive disorder (OCD) symptoms in patients with bipolar disorder (BD) is challenging. In this research, the therapeutic effects of risperidone on OCD symptoms in patients with BD are investigated. Forty-two patients with concurrent BD and OCD symptoms were randomly assigned to receive risperidone or a placebo in a blinded randomized placebo-controlled trial. The patients of both groups were in the euthymic phase of BD. OCD symptoms were measured by the Yale-Brown Obsessive Compulsive Behavior Scale (YBOCS) before the study initiation and at the 4th,8th, and 12th weeks in each group. All the patients completed the trial with no dropouts. At the initial evaluation, the risperidone and placebo groups did not differ significantly regarding their YBOCS scores. After 12 weeks of treatment, the OCD symptoms were significantly lower in the risperidone group compared to the placebo group [YBOCS: 5(3) vs. 11(6.5), P-value < 0.001]. The number of patients with more than 35% reduction in YBOCS was significantly higher in the risperidone group compared to the placebo group [20/21 (95.23%) vs. 10/21 (47.61%), P-value = 0.001]. Risperidone could effectively reduce OCD symptoms in BD patients. The treatment was safe and well tolerated.
期刊介绍:
International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes.
A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.