利培酮治疗儿童和青少年食欲调节激素的改变——SPACe研究的事后分析。

IF 3.1 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Jiayi Liang, Brenda C M de Winter, Rebecca A Hermans, Sanne M Kloosterboer, Susanne Kuckuck, Izgi Bayraktar, Liesbeth F C van Rossum, Manon H J Hillegers, Sander A A van den Berg, Birgit C P Koch, Bram Dierckx
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引用次数: 0

摘要

体重增加和代谢紊乱在接受抗精神病药物治疗的儿童和青少年中很常见,但其潜在机制尚不清楚,使预防和治疗复杂化。这项研究考察了利培酮对食欲调节激素(胰岛素、瘦素和生物瘦素)的影响,以及它们与体重随时间变化的关系。在事后分析中,我们评估了治疗期间和6个月随访期间食欲调节激素与BMI z分数的相关性。样本包括10名参与者(80%为男性,中位年龄9.7岁)。生物感知素显著增加(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alterations of appetite-regulating hormones in risperidone treated children and adolescents-a post hoc analysis of the SPACe study.

Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite-regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time. In a post hoc analysis, we evaluated the correlation of appetite-regulating hormones with BMI z-scores during treatment and at a 6-month follow-up. The sample consisted of 10 participants (80% male, median age 9.7 years). A significant increase in bioleptin (p < .05) and BMI z-scores was observed over the 6 month period. At baseline, HOMA-IR, insulin, leptin, and bioleptin were significantly correlated with the BMI z-score; however, these associations were no longer observed after 6 months of treatment. Additionally, higher risperidone exposure correlated with lower appetite-regulating hormone levels at the 6-month mark. These findings indicate that risperidone significantly affects appetite-regulating hormones in children and adolescents, potentially contributing to antipsychotic-induced weight gain.

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来源期刊
CiteScore
6.30
自引率
8.80%
发文量
419
审稿时长
1 months
期刊介绍: Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology features papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment. The Journal is recognised as one of the leading publications in its field. It is online only, publishes open access research through its OnlineOpen programme and is published monthly.
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