内毒素血液吸附在多器官功能障碍和极度内毒素活性的难治性脓毒性休克中的作用

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE

Critical Care Pub Date : 2025-05-20 DOI:10.1186/s13054-025-05371-1

Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Ivan Bajaña, Adolf Ruiz-Sanmartin, Juliana Bastidas, Carolina Maldonado, Pablo Nicolás-Morales, Sergi Cantenys-Molina, Juan José González, Nieves Larrosa, Ricard Ferrer

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引用次数: 0

摘要

内毒素感染性休克的特点是严重的器官衰竭和死亡率超过50%，强调了定制管理策略的关键必要性。监测内毒素活性可以指导血液吸附治疗顽固性脓毒性休克的起始和辅助治疗方向。因此，基于病理生理基础的干预可能会潜在地改善结果。这代表了在脓毒性休克辅助治疗管理中向精准医学迈出的一步，解决了在这一病理学中仍然没有充分定义的知识差距。尽管有潜力，但在内毒素活性极高（EAA≥0.9）的难治性脓毒性休克和多器官功能障碍患者中，内毒素血液吸附的疗效数据很少。

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Endotoxin hemoadsorption in refractory septic shock with multiorgan dysfunction and extreme endotoxin activity

Endotoxin septic shock is marked by severe organ failure and mortality rate that exceeds fifty percent, underscoring the critical need to tailor management strategies. Monitoring -endotoxin activity can guide the initiation and direction of adjunctive treatment for refractory septic shock through hemoadsorption. Thus, intervening based on the pathophysiological foundation may potentially improve outcomes. This represents a step towards precision medicine in the management of septic shock adjunctive therapies, addressing a knowledge gap in this pathology that remains insufficiently defined. Despite its potential, in the setting of refractory septic shock and multiorgan dysfunction with extreme endotoxin activity (EAA ≥ 0.9), the data about efficacy of endotoxin hemoadsorption is scarce.

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来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.