Study on Immune Characteristics and Gene Polymorphisms of Hypertension Patients.

Objective: Hypertension seriously endangers the health of patients. We studied the immune characteristics and gene polymorphisms of hypertension patients.

Methods: Forty-six hypertension patients (including 19 isolated hypertension patients without other diseases (IHP) and 27 complicated hypertension patients with related complications (CHP) and 28 healthy individuals (HCs) were recruited in this study. Immune cells and cytokines were detected by flow cytometry, immunoglobulins (Ig) were detected by immunoturbidimetry, and hormones were detected by chemiluminescence. Besides, gene polymorphisms were detected by PCR.

Results: Compared with HCs, the frequency and counts of circulating B cells increased significantly, while CD56dim natural killer (NK) cells decreased significantly in hypertension patients. The frequency and counts of circulating double positive T (DPT) cells increased significantly in IHP patients, while double negative T (DNT) cells decreased significantly in CHP patients as compared with HCs. Hormones and cytokines expression in hypertension patients increased significantly as compared with HCs. B cells were positively correlated with ACTH expression and strongly associated with hypertension. However, high ACTH levels can inhibit IgM expression in CHP patients. Besides, some CHP patients had gene polymorphisms in statins and antihypertensive drug metabolism, which may require individualized adjustments to drug use.

Conclusion: This study found the immune characteristics and gene polymorphisms of hypertension patients, which may provide new ideas and a theoretical basis for the prevention and treatment of hypertension.