果蝇嗅觉系统的综合解剖、功能和进化观点。

IF 6.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Richard Benton, Jérôme Mermet, Andre Jang, Keita Endo, Steeve Cruchet, Karen Menuz
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引用次数: 0

摘要

黑腹果蝇的嗅觉系统是所有动物神经系统中被研究最多的部分之一。它由大约50个独立的嗅觉神经元类别组成,并有几个相关的湿感和热感通路,已经受到不同类型的实验分析。然而,综合现有的信息是有限的数据不完整和不一致的命名法在文献中发现。在这项工作中,我们首先通过鉴定先前未表征的表达Or46aB的触角感觉神经元群体来“完成”周围感觉图谱,并定义了一个特殊的“杂交”嗅觉神经元类别,包括功能性的Or和Ir受体。其次,我们调查了发育,解剖,连接组,功能和进化研究,以生成这些感觉神经元通路的集成数据集和相关可视化,创造了前所未有的资源。第三,我们说明了数据集的效用,以揭示该感觉系统的不同组织属性之间的关系,以及这些特性引发的新问题。这些例子强调了这一资源在促进对这些神经回路的构建、功能和进化的进一步理解方面的力量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.

The Drosophila melanogaster olfactory system is one of the most intensively studied parts of the nervous system in any animal. Composed of ~50 independent olfactory neuron classes, with several associated hygrosensory and thermosensory pathways, it has been subject to diverse types of experimental analyses. However, synthesizing the available information is limited by the incomplete data and inconsistent nomenclature found in the literature. In this work, we first "complete" the peripheral sensory map through the identification of a previously uncharacterized antennal sensory neuron population expressing Or46aB, and the definition of an exceptional "hybrid" olfactory neuron class comprising functional Or and Ir receptors. Second, we survey developmental, anatomical, connectomic, functional, and evolutionary studies to generate an integrated dataset and associated visualizations of these sensory neuron pathways, creating an unprecedented resource. Third, we illustrate the utility of the dataset to reveal relationships between different organizational properties of this sensory system, and the new questions these stimulate. Such examples emphasize the power of this resource to promote further understanding of the construction, function, and evolution of these neural circuits.

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来源期刊
EMBO Reports
EMBO Reports 生物-生化与分子生物学
CiteScore
11.20
自引率
1.30%
发文量
267
审稿时长
1 months
期刊介绍: EMBO Reports is a scientific journal that specializes in publishing research articles in the fields of molecular biology, cell biology, and developmental biology. The journal is known for its commitment to publishing high-quality, impactful research that provides novel physiological and functional insights. These insights are expected to be supported by robust evidence, with independent lines of inquiry validating the findings. The journal's scope includes both long and short-format papers, catering to different types of research contributions. It values studies that: Communicate major findings: Articles that report significant discoveries or advancements in the understanding of biological processes at the molecular, cellular, and developmental levels. Confirm important findings: Research that validates or supports existing knowledge in the field, reinforcing the reliability of previous studies. Refute prominent claims: Studies that challenge or disprove widely accepted ideas or hypotheses in the biosciences, contributing to the correction and evolution of scientific understanding. Present null data: Papers that report negative results or findings that do not support a particular hypothesis, which are crucial for the scientific process as they help to refine or redirect research efforts. EMBO Reports is dedicated to maintaining high standards of scientific rigor and integrity, ensuring that the research it publishes contributes meaningfully to the advancement of knowledge in the life sciences. By covering a broad spectrum of topics and encouraging the publication of both positive and negative results, the journal plays a vital role in promoting a comprehensive and balanced view of scientific inquiry. 
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