Regina N Khramova, Tatyana I Eliseeva, Dmitry Y Ovsyannikov, Elena V Tush, Maxim A Karpenko, Anastasia A Shamrikova, Nailya I Kubysheva, Vilya A Bulgakova, Olga V Khaletskaya, Natalia A Geppe, Ildar Z Batyrshin
{"title":"儿童和青少年支气管哮喘患者体重指数对单核细胞和嗜酸性粒细胞水平的影响及其与肺活量测定参数的关系","authors":"Regina N Khramova, Tatyana I Eliseeva, Dmitry Y Ovsyannikov, Elena V Tush, Maxim A Karpenko, Anastasia A Shamrikova, Nailya I Kubysheva, Vilya A Bulgakova, Olga V Khaletskaya, Natalia A Geppe, Ildar Z Batyrshin","doi":"10.1155/carj/7534325","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objectives:</b> Excess adipose tissue induces low-intensity inflammation, which is an important pathogenetic factor adversely affecting the course of bronchial asthma (BA) in overweight/obese patients. The key effector cells of this inflammation are monocytes and macrophages. However, there are currently no studies characterising the effect of body mass index (BMI) on peripheral blood monocyte levels in children and adolescents with BA and their relationship with spirometric parameters reflecting bronchial patency. The aim of this study was to investigate the effect of BMI on peripheral blood monocyte and eosinophil levels and their relationship with spirometric parameters in children and adolescents with asthma. <b>Methods:</b> A single-centre, observational cross-sectional study was conducted. A total of 212 patients with asthma aged 7-17 years were studied. Anthropometric and spirometric parameters and the cellular composition of peripheral blood were evaluated. The children were divided into two groups: Group 1: with normal body weight (BW) and Group 2: with overweight/obesity. <b>Results:</b> In overweight/obesity patients, the number of peripheral blood monocytes (0.62 ± 0.19) was significantly higher compared to the group of normal weight patients (0.54 ± 0.15, <i>p</i> < 0.001). In contrast, eosinophil levels were statistically lower in the overweight/obesity group (0.22 [0.12; 0.42]) than in the normal weight patients (0.30 [0.14; 0.56], <i>p</i> = 0.039). A statistically significant negative correlation was found between the absolute number of monocytes and z FEV1/FVC, z MMEF<sub>25-75</sub> in the overweight/obesity group (<i>R</i> = -0.32, <i>p</i> = 0.005, <i>R</i> = -0.30, <i>p</i> = 0.007, respectively) and a statistically significant negative correlation between eosinophil count and z FEV1/FVC, z MMEF25-75 in normal weight patients (<i>R</i> = -0.20, <i>p</i> = 0.021, <i>R</i> = -0.22, <i>p</i> = 0.010, respectively). <b>Conclusions:</b> The results obtained may indicate a modifying effect of overweight/obesity on inflammation endotypes in children and adolescents with BA.</p>","PeriodicalId":9416,"journal":{"name":"Canadian respiratory journal","volume":"2025 ","pages":"7534325"},"PeriodicalIF":2.1000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088844/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Influence of Body Mass Index on Monocytes and Eosinophil Levels and Their Relationship With Spirometric Parameters in Children and Adolescents With Bronchial Asthma.\",\"authors\":\"Regina N Khramova, Tatyana I Eliseeva, Dmitry Y Ovsyannikov, Elena V Tush, Maxim A Karpenko, Anastasia A Shamrikova, Nailya I Kubysheva, Vilya A Bulgakova, Olga V Khaletskaya, Natalia A Geppe, Ildar Z Batyrshin\",\"doi\":\"10.1155/carj/7534325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objectives:</b> Excess adipose tissue induces low-intensity inflammation, which is an important pathogenetic factor adversely affecting the course of bronchial asthma (BA) in overweight/obese patients. The key effector cells of this inflammation are monocytes and macrophages. However, there are currently no studies characterising the effect of body mass index (BMI) on peripheral blood monocyte levels in children and adolescents with BA and their relationship with spirometric parameters reflecting bronchial patency. The aim of this study was to investigate the effect of BMI on peripheral blood monocyte and eosinophil levels and their relationship with spirometric parameters in children and adolescents with asthma. <b>Methods:</b> A single-centre, observational cross-sectional study was conducted. A total of 212 patients with asthma aged 7-17 years were studied. Anthropometric and spirometric parameters and the cellular composition of peripheral blood were evaluated. The children were divided into two groups: Group 1: with normal body weight (BW) and Group 2: with overweight/obesity. <b>Results:</b> In overweight/obesity patients, the number of peripheral blood monocytes (0.62 ± 0.19) was significantly higher compared to the group of normal weight patients (0.54 ± 0.15, <i>p</i> < 0.001). In contrast, eosinophil levels were statistically lower in the overweight/obesity group (0.22 [0.12; 0.42]) than in the normal weight patients (0.30 [0.14; 0.56], <i>p</i> = 0.039). A statistically significant negative correlation was found between the absolute number of monocytes and z FEV1/FVC, z MMEF<sub>25-75</sub> in the overweight/obesity group (<i>R</i> = -0.32, <i>p</i> = 0.005, <i>R</i> = -0.30, <i>p</i> = 0.007, respectively) and a statistically significant negative correlation between eosinophil count and z FEV1/FVC, z MMEF25-75 in normal weight patients (<i>R</i> = -0.20, <i>p</i> = 0.021, <i>R</i> = -0.22, <i>p</i> = 0.010, respectively). <b>Conclusions:</b> The results obtained may indicate a modifying effect of overweight/obesity on inflammation endotypes in children and adolescents with BA.</p>\",\"PeriodicalId\":9416,\"journal\":{\"name\":\"Canadian respiratory journal\",\"volume\":\"2025 \",\"pages\":\"7534325\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088844/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian respiratory journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/carj/7534325\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian respiratory journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/carj/7534325","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
摘要
目的:过量脂肪组织诱导低强度炎症是影响超重/肥胖患者支气管哮喘(BA)病程的重要致病因素。这种炎症的关键效应细胞是单核细胞和巨噬细胞。然而,目前还没有研究描述体重指数(BMI)对BA儿童和青少年外周血单核细胞水平的影响及其与反映支气管通畅的肺活量指标的关系。本研究的目的是探讨BMI对儿童和青少年哮喘患者外周血单核细胞和嗜酸性粒细胞水平的影响及其与肺活量测定参数的关系。方法:采用单中心、观察性横断面研究。研究对象为212例7 ~ 17岁哮喘患者。评估人体测量和肺活量测定参数以及外周血细胞组成。将患儿分为体重正常组(BW)和超重/肥胖组(2组)。结果:超重/肥胖患者外周血单核细胞数(0.62±0.19)明显高于正常体重组(0.54±0.15,p < 0.001)。相比之下,超重/肥胖组的嗜酸性粒细胞水平在统计学上较低(0.22 [0.12;0.42])比正常体重患者(0.30 [0.14;0.56], p = 0.039)。超重/肥胖组单核细胞绝对数量与z FEV1/FVC、z MMEF25-75呈显著负相关(R = -0.32, p = 0.005, R = -0.30, p = 0.007),正常体重组嗜酸性粒细胞计数与z FEV1/FVC、z MMEF25-75呈显著负相关(R = -0.20, p = 0.021, R = -0.22, p = 0.010)。结论:所获得的结果可能表明超重/肥胖对BA儿童和青少年炎症内型的改善作用。
The Influence of Body Mass Index on Monocytes and Eosinophil Levels and Their Relationship With Spirometric Parameters in Children and Adolescents With Bronchial Asthma.
Objectives: Excess adipose tissue induces low-intensity inflammation, which is an important pathogenetic factor adversely affecting the course of bronchial asthma (BA) in overweight/obese patients. The key effector cells of this inflammation are monocytes and macrophages. However, there are currently no studies characterising the effect of body mass index (BMI) on peripheral blood monocyte levels in children and adolescents with BA and their relationship with spirometric parameters reflecting bronchial patency. The aim of this study was to investigate the effect of BMI on peripheral blood monocyte and eosinophil levels and their relationship with spirometric parameters in children and adolescents with asthma. Methods: A single-centre, observational cross-sectional study was conducted. A total of 212 patients with asthma aged 7-17 years were studied. Anthropometric and spirometric parameters and the cellular composition of peripheral blood were evaluated. The children were divided into two groups: Group 1: with normal body weight (BW) and Group 2: with overweight/obesity. Results: In overweight/obesity patients, the number of peripheral blood monocytes (0.62 ± 0.19) was significantly higher compared to the group of normal weight patients (0.54 ± 0.15, p < 0.001). In contrast, eosinophil levels were statistically lower in the overweight/obesity group (0.22 [0.12; 0.42]) than in the normal weight patients (0.30 [0.14; 0.56], p = 0.039). A statistically significant negative correlation was found between the absolute number of monocytes and z FEV1/FVC, z MMEF25-75 in the overweight/obesity group (R = -0.32, p = 0.005, R = -0.30, p = 0.007, respectively) and a statistically significant negative correlation between eosinophil count and z FEV1/FVC, z MMEF25-75 in normal weight patients (R = -0.20, p = 0.021, R = -0.22, p = 0.010, respectively). Conclusions: The results obtained may indicate a modifying effect of overweight/obesity on inflammation endotypes in children and adolescents with BA.
期刊介绍:
Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.